沙眼衣原体主要外膜蛋白亚单位疫苗的研究进展

Research Progress in the Major Outer Membrane Protein-based Subunit Vaccine Against Chlamydia Trachomatis

沙眼衣原体主要外膜蛋白的亚单位疫苗成分无毒力,能诱导中和抗体和特异性细胞免疫反应产生,对机体起到预防和一定的特异性治疗作用,是有前途的新型疫苗之一。目前,研究的重点集中于主要外膜蛋白功能构象、有效T-B表位筛选及选择合适的载体佐剂增强免疫原性,并探讨恰当的接种途径,诱导高效的抗体和细胞免疫,同时加强黏膜防御。

A Chlamydia trachomatis major outer membrane protein-based（MOMP）subunit vaccine containing no pathogenic component,can induce both local neutralizing antibodies and cell-mediated immune response to limit infection.This vaccine is one of the most promising new vaccines,playing roles in prevention and specific treatment.All of the conformation of MOMP subunit,prediction of effective T and B cell epitopes,the delivery system and adjuvant,are greatly related to the immunogenicity of vaccine,so is the inoculation.Through the resolving of these difficulties,the effective Ct-MOMP subunit vaccine,inducing systemic and mucosal once it is initiated,may be developed.