EGF在幽门螺杆菌感染同时长期饮酒引起胃黏膜癌相关性病变中的作用

Function of EGF on Gastric Cancer-Related Lesion Caused by Helicobacter Pylori Infection with Chronic Alcohol Drinking

目的探讨幽门螺杆菌感染同时长期饮酒引起胃黏膜癌相关性病变与EGF之间的关系。方法 2007年1月～2010年12月对符合条件的幽门螺杆菌合并长期饮酒56例和长期饮酒64例患者进行内镜下胃黏膜活检组织的病理学观察,同时抽静脉血及胃液用ELISA法检测EGF浓度。结果 (1)幽门螺杆菌合并长期饮酒组中胃黏膜轻度和中重度萎缩亚组患者血清EGF浓度均分别明显高于长期饮酒组中胃黏膜轻度和中重度萎缩亚组患者血清EGF浓度,P均=0.00。(2)幽门螺杆菌合并长期饮酒组中胃黏膜轻度和中重度肠化亚组患者血清EGF浓度均分别明显高于长期饮酒组中胃黏膜轻度和中重度肠化亚组患者血清EGF浓度,P均=0.00。(3)幽门螺杆菌合并长期饮酒组中胃黏膜有或无不典型增生亚组患者血清EGF浓度均分别明显高于长期饮酒组中胃黏膜有或无不典型增生亚组患者血清EGF浓度,P=0.02或0.00。(4)两组各亚组患者之间胃液EGF浓度对比,P均>0.05。结论幽门螺杆菌感染合并长期饮酒患者血液中EGF参与胃黏膜癌相关性病变的发生和发展,胃液EGF与胃黏膜癌相关性病变的之间关系有待于进一步探讨。

Objective To explore the relationship between EGF and gastric cancer-related lesion caused by helicobacter pylori infection and chronic alcohol drinking.Method A study of gastric mucosa acquired by gastroscope was conducted in 56 patients of helicobacter pylori infection with chronic alcohol drinking and 64 patients of chronic alcohol drinking from January 2007 to December 2010.EGF in venous blood and gastric juice were taken and examined by enzymelinked immunosorbent assay.Results（1） The concentration of serum EGF in the slight and moderate-severe gastric atrophy subgroups was significantly higher in patients with helicobacter pylori infection and chronic alcohol drinking and than that in the subgroups in patients with chronic alcohol drinking（P=0.00）.（2） The concentration of serum EGF in the slight and moderate-severe intestinal metaplasia subgroups was significantly higher in patients with helicobacter pylori infection and chronic alcohol drinking than that in the subgroups in patients with chronic alcohol drinking（P=0.00）.（3） The concentration of serum EGF in dysplasia or no-dysplasia subgroup was significantly higher in patients with helicobacter pylori infection and chronic alcohol drinking than that in the subgroups in patients with the chronic alcohol drinking group（P=0.02 or 0.00）.（4） Contrast on each subgroup between two groups,EGF concentration in gastric juice was not statistically different（P 0.05）.Conclusions Serum EGF plays a role in the origin and development of gastric cancer-related lesion in patients with helicobacter pylori infection with chronic alcohol drinking.It is remained to be discussed further on the connection between EGF in gastric juice and gastric cancerrelated lesion.