摘要
目的评价二次肿瘤细胞减灭术对复发性上皮性卵巢癌患者治疗的临床意义。方法回顾性分析了本院1998～2005年间收治的52例复发性上皮性卵巢癌患者的临床资料。24例接受了二次肿瘤细胞减灭术(手术组),术后辅以铂类为基础的化疗。另外28例患者只接受了以铂类为基础的化疗(对照组)。结果手术组患者复发后中位生存期为32.5个月,对照组中位生存期为18.4个月,差异有统计学意义(P<0.05)。手术组中,生存期受手术后残余病灶的影响,残余病灶直径<2cm,中位生存期为41.3个月,残余病灶直径>2cm,中位生存期为28.5个月,差异有统计学意义(P<0.05)。结论二次肿瘤细胞减灭术可以改善复发性上皮性卵巢癌患者的预后。
Objective To assess the clinical benefit of secondary cytoreductive surgery in patients with recurrent ovarian epithelial cancer.Method A retrospective analysis of 52 patients with recurrent epithelial ovarian cancer treated in our department between 1998 and 2005 was conducted.Twenty-four patients underwent secondary cytoreductive surgery assisted by platinum based chemotherapy（operation group）,and other 28 patients were treated by chemotherapy only（control group）.Results Patients in operation group had a median survival time of 32.5 months after recurrence,which was significantly longer than patients in control group（18.4 months）（P0.05）.In operation group,the survival was influenced by the residual focus.When residual focus was 2cm,median survival was 41.3 months.When residual focus diameter was 2cm,median survival was 28.5 months.There was a significant difference（P0.05）.Conclusions The secondary cytoreductive surgery might improve the prognosis of patients with recurrent epithelial ovarian cancer.
出处
《现代诊断与治疗》
CAS
2012年第2期71-73,共3页
Modern Diagnosis and Treatment
