104例青年人黄斑色素密度的调查分析

Analysis of correlative factors of macular pigment optical density in 104 young people

目的研究中国青年人黄斑色素密度(MPOD),以及MPOD与屈光度、性别、吸烟、饮酒、年龄相关性黄斑变性家族史等相关因素的分析。方法 2007级和2008级就读于北京大学医学部预防医学系学生56人以及社会青年志愿者48人,共计104人,208只眼纳入研究,所有受试者完整回答调查问卷,包括是否有吸烟史、饮酒史、黄斑变性家族史等问题,并进行统一流程的屈光度的检查,所有受试者采用异色闪烁光度测量法进行黄斑色素密度的测量。结果全部受试者共208只眼的MPOD均值为0.625±0.191,对所有男性与女性、主导眼与非主导眼、有吸烟史与无吸烟史和有饮酒史与无饮酒史的MPOD值进行比较,差异无统计学意义;对有黄斑变性家族史与无家族史的研究者MPOD值进行比较,差异有统计学意义;MPOD值与屈光度无相关性(r=-0.107,P=0.124)。结论有黄斑变性家族史的青年人MPOD值下降。

Objective To survey macular pigment optical density of young people in China,as well as the relationship between MPOD and correlative factors,such as refractive diopter,gender,smoking,alcohol consumption,and family history of age-related macular degeneration.Methods 48 community youth volunteers and 56 students of 2007 or 2008,studied at department of preventive medicine,college of health science,Peking University,were enrolled in the study.All participants completed a simple questionnaire,including smoking history,drinking history,family history of macular degeneration,and a unified examination of refraction process.All the subjects used heterochromatic flicker photometry method for measuring macular pigment optical density.Results The mean of MPOD value of 208 eyes was（0.625 ± 0.191）.There was no significant difference between male researchers and female researchers,non-dominant eye and dominant eye,subjects without smoking and with smoking,subjects without drinking and with drinking（P 0.05）.The difference of MPOD values between subjects having AMD family history and subjects having no family history was significant.MPOD did not correlated with the diopter value（r=-0.107,P=0.124,P 0.05）.Conclusion MPOD value of young people with family history of macular degeneration decreased.