肝癌干细胞的研究进展

Advance of stem cells in primary hepatic carcinoma

我国是原发性肝癌高发的国家,其发病率、死亡率约占全球的一半以上。尽管目前肝癌的诊断和治疗有了许多新的进展,但是总体疗效仍不满意。近年来的研究表明,肝癌中存在着一群具有干细胞特征、能自我更新、自我无限增殖并具有多向分化潜能的细胞,即肝癌干细胞,这对重新认识肝癌的发生、发展、预后转归以及指导临床治疗将起到极为重要的作用。本文通过复习肝癌干细胞相关文献,就肝癌干细胞起源、分选及相关治疗的研究进展作一综述。

China is a country with high incidence of primary hepatic carcinoma,which incidence and mortality take about over a half of the world.Although there is a great improvement in the diagnosis and treatment of liver cancer in recent days,the overall effect is still not satisfied.According to the research in recent years,there is a kind of cell existed in primary hepatic carcinoma with stem cells characteristics,which can be self-updated and self-proliferated unlimitedly with multi-differentiation potentiality,that is the liver cancer stem cells,which has extremely important function in re-understanding of the occurrence,development and prognosis outcome of primary hepatic carcinoma as well as guiding the clinical treatment.According to the review of the relevant literatures about primary hepatic carcinoma stem cells,this paper makes a summary of the origin,identification and the development of the newest research on the relevant treatment of primary hepatic carcinoma stem cells.