期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

过氧化物酶体增殖因子活化受体γ与缺血性卒中

原文传递
导出
摘要 过氧化物酶体增殖因子活化受体（PPARs）属于核受体超家族中的一员．参与许多生理调控如糖代谢、脂肪代谢、细胞生长及分化。PPAR-γ则与细胞葡萄糖摄取、抗动脉粥样硬化和免疫调控有关，PPAR-γ的活化有效减轻了神经变性和脑内的炎性反应。本文就PPAR-γ在缺血性脑卒中病理损伤过程中发挥的神经保护作用相关研究作一综述。
作者 刘建荣 王琳
机构地区 上海交通大学医学院附属瑞金医院神经内科神经病学研究所
出处 《内科理论与实践》 2012年第2期82-85,共4页 Journal of Internal Medicine Concepts & Practice
关键词 过氧化物酶体增殖因子活化受体Γ 缺血性卒中 神经保护
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献21

  • 1Elkind MS,Luna JM,Coffey CS. The levels of inflammatory markers in the treatment of stroke study (LIMITS):inflammatory biomarkers as risk predictors after lacunar stroke[J].International Journal of Stroke,2010,(02):117-125.
  • 2Loor G,Kondapalli J,Iwase H. Mitochondrial oxidant stress triggers cell death in simulated ischemiareperfusion[J].Biochimica Et Biophysica Acta,2011,(07):1382-1394.
  • 3Zuhayra M,Zhao Y,von Forstner C. Activation of cerebral peroxisome proliferator-activated receptors γ(PPARγ) reduces neuronal damage in the substantia nigra after transient focal cerebral ischaemia in the rat[J].Neuropathology and Applied Neurobiology,2011,(07):738-752.
  • 4Medhi B,Aggarwal R,Chakrabarti A. Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice[J].Indian Journal of Experimental Biology,2010,(08):793-799.
  • 5Gamboa J,Blankenship DA,Niemi JP. Extension of the neuroprotective time window for thiazolidinediones in ischemic stroke is dependent on time of reperfusion[J].Neuroscience,2010,(03):846-857.
  • 6Zhao Y,Patzer A,Gohlke P. The intracerebral application of the PPARγ-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain[J].European Journal of Neuroscience,2005,(01):278-282.
  • 7狄政莉,田晔,马红兵,杜芳,雷辉,张格娟,梁画荻.缺氧/复氧损伤对大鼠海马神经元过氧化物酶体增殖物激活受体γ表达的影响[J].中南大学学报（医学版）,2009,34(12):1238-1242. 被引量：5
  • 8Hsu WH,Lee BH,Liao TH. Monascus-fermented metabolite monascin suppresses inflammation via PPAR-γ regulation and JNK inactivation in THP-1 monocytes[J].Food and Chemical Toxicology,2012,(05):1178-1186.
  • 9Yi JH,Park SW,Brooks N. PPARγ agonist rosiglitazone is neuroprotective after traumatic brain injury via anti-inflammatory and anti-oxidative mechanisms[J].Brain Research,2008.164-172.
  • 10Sadaghiani MS,Javadi-Paydar M,Gharedaghi MH. Antidepressant-like effect of pioglitazone in the forced swimming test in mice:the role of PPAR-γ receptor and nitric oxide pathway[J].Behavioural Brain Research,2011,(02):336-343.

二级参考文献16

  • 1狄政莉,牛小麟,魏瑾,李永勤,陈改玲,汪南平.PPAR-γ在自发性高血压大鼠血管平滑肌表达的增龄性变化[J].四川大学学报（医学版）,2006,37(2):204-207. 被引量：4
  • 2Castrillo A, Tontonoz P. Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation [J]. Annu Rev Cell Dev Biol, 2004, 20 (2) : 455- 480.
  • 3Marx N, Duez H, Fruchart J C, et al. Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells [J].Circ Res, 2004, 94 (9) :1168-1178.
  • 4Sasaki M, Jordan P, Welbourne T, et al. Troglitazone, a PPAR- gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF- alpha [J]. BMC Physiol,2005,5(1) :3-12.
  • 5Schintu N, Frau L, Ibba M, et al. PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease[J]. Eur J Neurosci, 2009,29(5) :954-963.
  • 6Natarajan C, Muthaian G, Barak Y, et al. Peroxisome proliferators - activated receptor- gaining- deficient heterozygous mice develop an exacerbatedneural an tigen-induced Thl response and experimental allergic encephalomyelitis [J]. J Immunol,2003,171 (11) :5743-5750.
  • 7Ijpenberg A, Jeannin E, Wahli W, et al. Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA: a functional analysis of the malic enzyme gene PPAR response element [J]. J Biol Chem, 1997,272 (1) : 108-117.
  • 8Hsueh W A, Law R E. PPARγ and atherosclerosis: effect oncell growth and movement [J]. Arterioscler Thromb Vase Biol,2001,21 (12) :1891-1895.
  • 9Diep Q N, Schiffrin E L. Increased expression of peroxisome proliferator- activated receptor- alpha and - gamma in blood [J]. Hypertension,2001,38(2) :249-254.
  • 10Moreno S, Farioli Vecchioli S, Ceru M P. Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS [J]. Neuroscience, 2004,123(1) :131-145.

共引文献4

内科理论与实践
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部