In Vitro Modeling of Central Nervous System Myelination and Remyelination

本文对体外培养中髓鞘形成与髓鞘再生的研究手段进行综述。探讨各种研究手段的运用历史及优缺点,这些与各实验的研究目的有关。本文还对髓鞘形成尤其是髓鞘再生量化的重要性及存在的问题进行讨论。最后,对这些研究手段在未来的发展进行展望。

This review aims to summarize the current techniques to study myelination and remyelination in culture systems.We attempt to put these into historical context , and to identify the strengths and weaknesses of each approach , which vary depending on the experimental question to be tested.We discuss the difficulty and importance of quantification of myelination and in particular remyelination.Finally , we provide our predictions of how these techniques will and should develop in the future.