食管胃结合部腺癌淋巴结转移规律及其对临床指导意义

Lymphatic metastasis rules of adenocarcinoma of the esophagogastric junction and their significances for clinical management

在过去的30年里,虽然胃癌的发病率有所下降,但仍是世界范围内病死率最高的疾病之一。手术仍是胃癌的最佳治疗手段。肿瘤的位置不仅影响手术方式,而且影响存活率。与远端胃癌相比,近端胃癌的TNM分期更高,整体存活率更差。淋巴结的侵犯程度与整体存活率密切相关,熟悉食管胃结合部腺癌(AEG)的淋巴结转移规律,选择合适的手术方式及淋巴结清扫范围,可明显提高AEG的整体存活率。

Despite the decrease in incidence of gastric cancer during the last 30 years, the disease remains one of the leading causes of worldwide cancer death. Surgery is the only potentially curative treatment fer gastric cancer. The location of the cancer must be described as it is important, not only for assessing appropriateness of surgical approach, but also for survival. Proximal gastric cancer has been associated with advanced stage and worse owrall survival compared with distal cancer. Nodal status is an important prognostic indicator for gastric cancer. Knowing the rules of lymphatic metastasis in esophagogastric junction cancer, determining an optimal surgical approach and extent of lymph node dissection, may have a better overaill survival of the esophagogastric junction cancer.