急性心肌梗死心绞痛患者血清微量元素测定分析

Analysis of serum trace elements in patients with acute myocardial in farction or with anfina pectoris

目的 对冠心病患者的血清微量元素进行分析，以期明确微量元素与冠心病的发生、发展的关系。方法 ５２例冠心病患者分为两组：①急性心肌梗死（ＡＭＩ）组２８ 例，②心绞痛（ＡＧ） 组２４ 例，并以３０ 例健康者作为对照组分别测定其血清锌（Ｚｎ）、铜（Ｃｕ）、铁（Ｆｅ） 、锰（Ｍｎ） 浓度。结果 ＡＧ组与ＡＭＩ组的血清Ｚｎ 值显著低于对照组（分别为０－７５ ±０－３８ μｇ／Ｌ，０－３１±０－１９ μｇ／Ｌ，１－０２±０－５３ μｇ／Ｌ，Ｐ均＜０－０１），ＡＭＩ组与ＡＧ 组Ｃｕ 值显著高于对照组（ 分别为１－４５±０－７９ μｇ／Ｌ，１－０９ ±０－６２ μｇ／Ｌ，０－７０±０－３９ μｇ／Ｌ，Ｐ均＜０－０１） 。结论 ①冠心病患者血清Ｚｎ 降低，我们推测机体为了减轻损害使Ｚｎ 的消耗增加有关。②冠心病患者血清Ｃｕ 升高，我们推测由于冠心病患者大量细胞缺血缺氧甚至坏死导致大量Ｃｕ 释放入血有关。

Objective Serum trace elements in patients with coronary heart disease (CHD)was measured.The aim of the present study was to determine the relation between the trace elements and CHD Methods Totally 52 patients with CHD included two groups below:①Acute myocardial infarction group (AMI):28 cases.②Angina group (AG):24 cases,There were thirty normal controls.The concentrations of serum trace elements(Cu、Zn、Fe、Mn)were measured above cases.Results Serum levels of Zn was significantly lower in patients with AG(0 75±0 38 μg/L)and AMI(0 31±0 19 μg/L)than that of NC(1 02±0 53 μg/L)( P <0 01 entirely).Serum levels of Cu were significantly higher in patients with AG(1 09±0 62 μg/L)and AMI(1 45±0 79 μg/L)than that of NC(0 70±0 39 μg/L)( P <0 01 entirely).Conclusions Lower serum levels of Zn in patients with CHD might be associated with increased consume.Higher serum levels of Cu in patients might be associated with increased release. [