Micro-CT及三维打印机制备仿生化数字化组织工程指骨支架材料的研究

Preparalion of biomlmelic, digital phalanx scaffold for tissue engineering using micro-CT and lhree- dimensional printer

目的采用Micro-CT扫描采集人类拇指末节指骨三维微观数据并使用三维立体打印机，建立三维指骨支架材料模型，对仿生化、智能化组织工程支架材料的体外构建进行初步探讨。方法对成年男性新鲜拇指末节标本进行MJcro-CT扫描，所得的原始DICOM数据为基础，通过Miinic8软件三维处理得到宏观及微观仿生的三维打印STL文件，并通过三维打印机打印出指骨支架三维模型。结果采用Micro-CT扫描得到的数据用Mimics三维医学处理软件处理后，可直接用三维立体打印机快速成型构建仿生化、数字化组织工程指骨支架材料。结论基于Micro-CT及三维打印机的仿生化、智能化组织工程骨建模技术对治疗指骨毁损伤有重要的临床意义，且有良好的应用前景。

Objective To prepare biomimetic, intelligent scaffold for tissue engineering of thumb distal phalanx using gathered three-dimensional （3D） data. Methods Distal phalanxes from fresh adult cadaver thumbs were subject to micro -CT scanning. The DICOM data from micro-CT scans were processed using Mimics software to form the macro and micro biomimetie 3D printing STL fde. 3D printer was then used to print out a scaffold of a phalanx. Results The data acquired by miero-CT scanning can be rapidly prototyped after being edited with Mimics and directly used by 3D printing system to construct a biomimefie, intelligent scaffold. Conclusion Biomimetic, intelligent scaffold based on micro-CT and 3D printing has clinical significance in reconstruction of destructed thumbs.