慢性病毒性肝炎与可溶性细胞间粘附分子-1关系的研究

Detection and importance of soluble intercellular adhesion molecule-1 in patients with chronic viral hepatitis

目的 探讨可溶性细胞间粘附分子 - 1(sICAM - 1)与病毒性肝炎的关系。方法 用ELISA法检测 6 1例慢性乙型肝炎及慢性重型肝炎患者的血清sICAM - 1。结果 各组患者的sICAM - 1水平均高于正常人 (P <0 0 1)。而各组患者之间的sICAM水平 ,以慢性重型肝炎患者最高 ,中度慢性肝炎次之 (P <0 0 1) ,轻度慢性肝炎较低 (P <0 0 1)。sICAM水平与血清丙氨酸转氨酶及总胆红素水平呈显著正相关 (P <0 0 1) ,与血清白蛋白水平呈显著负相关 (P <0 0 1) ,与体内乙肝病毒的存在及复制无关。结论 sICAM - 1是一项敏感的。

Objective In order to probe into the relationship between soluble intercellular adhesion molecule-1(sICAM-1) and viral hepatitis.Methods Serum levels of sICAM-1 were measured by ELISA in 61 patients with chronic hepatitis B.Results Serum levels of sICAM-1 were markedly elevated in patients with chronic severe hepatitis when compared with that of the patients with chronic moderate hepatitis(P<0 01),serum levels of sICAM-1 of the latter were significantly higher than that in patients with chronic mild hepatitis(P<0 01).Serum levels of sICAM-1 of the patients were all significantly higher than that of control(P<0 01).Spearman analysis showed that levels of sICAM-1 were significantly positively correlated with serum ALT and total bilirubin(P<0 01),and had a significant negative correlation with serum albumin(P<0 01).There was no significant difference between the sICAM-1 levels of patients with positive and negative HBV replicated marker(P<0 05).Conclusion The results suggested that serum levels of sICAM-1 may be regarded as a useful marker in the evaluation of the activity of inflammation and the extent of liver damage in patients with chronic hepatitis B.