摘要
目的系统评价杀伤细胞免疫球蛋白样受体(KIR)基因多态性与HIV感染/AIDS的相关性。方法通过文献检索Medline和中国生物医学文献(CBM)数据库等,收集KIR基因多态性与HIV感染/AIDS关系的全文文献,剔除不符合要求者,在全面回顾文献的基础上对各病例对照研究结果进行Meta分析。结果 6篇有关KIR基因多态性与HIV/AIDS关系的研究认为KIR3DS1基因是HIV感染或(和)艾滋病的保护基因(P<0.05),其合并OR值为0.65,95%CI为0.48～0.88。结论携带KIR3DS1基因可能降低HIV/AIDS的危险性,其他KIR基因与HIV/AIDS之间的关联无显著性。
Objective To evaluate the association between genetic polymorphism of killer cell immunoglobulin-like receptors （KIR） and HIV/AIDS in the population of the world. Methods The OR of K/R gene distributions in the population with risk factors of HIV/AIDS against the population without the risk factors was analyzed. All the relevant studies were collected from databases e. g. , Medline and CBM. The studies of poor quality were eliminated, and the risk of publication bias was evaluated. The Meta-analysis was applied for investigating heterogeneity among individual studies and summarizing the results across studies. Results KIR3DS1 was the protective gene of HIV/AIDS. The pooled OR was 0.65, 95% CI was 0.48 to 0.88 in 6 relative studies. Condusion KIR3DS1 genes in case-control study may be associated with HIV/AIDS. No certain relationship between other K/R genes and HIV/AIDS was found.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2012年第3期170-173,共4页
Chinese Journal of Clinical Laboratory Science
基金
国家自然科学基金(30872156)
关键词
杀伤细胞免疫球蛋白样受体
基因多态性
人类免疫缺陷病毒
艾滋病
荟萃分析
killer cell immunoglobulin-like receptors
genetic polymorphism
human immunodeficiency virus
acquired immunodefi- ciency syndrome
Meta-analysis
