在体光学分子影像技术在乳腺癌基础及临床研究中的应用

Basic research and clinical application of optical molecular imaging in breast cancer

在体光学分子影像作为一种快速发展的生物医学影像技术，以其实时、定量及非侵入性等特点，已被广泛应用于各学科的研究中。光学分子影像技术在监测乳腺癌的远处转移、检测肿瘤细胞的凋亡、细胞周期、细胞乏氧与肿瘤血管生成、观察ER介导的分子路径、观察乳腺癌干细胞等基础研究领域及在乳腺癌早期诊断、引导前哨淋巴结活组织检查、药物疗效评价、检测乳腺癌原癌基因人类表皮生长因子受体2（HER一2）表达等基础研究及临床应用中有着良好的前景。

As a rapidly developing biomedical imaging technology, in vivo optical molecular imaging has been widely applied in various research fields owing to its unique real-time, quantitative and noninvasive characteristics. The applications of in vivo optical imaging technology in the basic and clinical research of breast cancer were reviewed, including detection of distant metastasis, tumor apoptosis, cell cycle, hypoxia and angiogenesis, ER-mediated molecular pathway, breast cancer stem cells, early diagnosis, sentinel node biopsy, evaluation of drug efficacy and detection of human epidermal growth factor receptor-2 （HER-2） exoression. They all seem to have a promising potential in in vivo optical molecular imaging.