肺炎克雷伯氏菌临床分布和药物敏感性分析

Analysis of clinical distribution and drug resistance of Klebsiella pneumoniae

目的分析我院肺炎克雷伯氏菌的分布和药物敏感情况。方法回顾性分析2008年1月-2011年4月从临床标本中分离出的肺炎克雷伯氏菌相关资料。结果共分离出2536株肺炎克雷伯氏菌。其中,耐药率最高的是氨苄西林(98.62%),对美洛培南、头孢哌酮/舒巴坦和亚胺培南仍保持较高的敏感性,但已有耐药株的出现。超广谱β内酰胺酶(ESBLs)检出率为34.98%。结论及时分析本地区细菌的药物敏感情况对指导本地区临床医生的用药具有重要意义。

Objective To analyze the clinical distribution and drug resistance of Klebsiella pneumoniae.Methods Data of Klebsiella pneumoniae isolated from clinical specimens from January 2008 to April 2011 were retrospectively analyzed.Results A total of 2536 cases of Klebsiella pneumoniae was isolated,of which the highest rate of drug resistance was to ampicillin（98.62%）.Klebsiella pneumoniae remained to be highly sensitive to meropenem,cefoperazone/sulbactam and imipenem,but the drug-resistant strains emerged.The detection rate of extended-spectrum β-lactamases（ESBLs） was 34.98%.Conclusion The timely analysis of bacteria drug-sensitivity is important to guide clinical treatment in this region.