胃癌嗜铬蛋白A与表皮生长因子受体表达的关系及意义

Relationship and significance of CGA and EGFR expression in human gastric carcinoma

目的探讨胃癌嗜铬蛋白A(CGA)与表皮生长因子受体(EGFR)表达的关系及意义。方法应用免疫组织化学ABC法检测103例手术切除的标本中胃癌组织及癌旁正常组织CGA和EGFR的表达。结果胃癌组织中CGA及EGFR表达率分别为39.8%和41.7%,均明显高于癌旁正常组织的2.9%和0(P<0.01)。CGA与EGFR表达均与肿瘤组织学类型、浸润深度、TNM分期、分化程度、有无淋巴结转移及远处转移相关。胃癌组织中,CGA阳性组EGFR的表达率明显高于CGA阴性组(65.9%vs.25.8%)。CGA与EGFR表达呈正相关(r=0.498,P<0.05)。结论 CGA、EGFR在胃癌组织中高表达,两者表达相关且与胃癌的侵袭、转移有关。

Objective To investigate the relationship and significance of chromogranin A（CGA） and epidermal growth factor receptor（EGFR） expression in human gastric carcinoma.MethodsThe expressions of CGA and EGFR in gastric cancer and tumor-adjacent normal tissues were detected by immunohistochemical ABC staining method in 103 surgical specimens.Results The positive expression rates of CGA and EGFR in the gastric cancer tissues were significantly higher than those in the tumor-adjacent normal tissues（39.8% vs.2.9% and 41.7% vs.0,respectively）（P〈0.01）.The expressions of CGA and EGFR in gastric cancer were correlated with the histological type,depth of invasion,TNM classification,differenciation,lymph node and distant metastasis.The expression rate of EGFR was higher in CGA positive tumor than that in CGA negative（65.9% vs.25.8%）.The expression of EGFR was positively correlated with that of CGA（r=0.492,P〈0.05）.ConclusionThe CGA and EGFR are higherly expressed in human gastric carcinoma,which is positively correlated each other and is related with its invasion and metastasis.