摘要
Toll样受体(TLRs)在机体防御反应中的重要作用已经被多数人所认识,而通过TLRs激动剂来调节免疫反应以达到预防和治疗疾病的目的,则成为近几年新的研究热点。本文就TLRs激动剂的应用研究进展作一综述。
出处
《江苏医药》
CAS
CSCD
北大核心
2012年第7期834-836,共3页
Jiangsu Medical Journal
基金
江苏省自然科学基金课题(BK2008327)
参考文献16
-
1嵇武,李宁.Toll样受体与临床疾病关系的研究进展[J].中国误诊学杂志,2007,7(16):3709-3711. 被引量:7
-
2Parker LC,Pr ince LR,Sabroe I.Translational mini-reviewSeries on Toll-like receptors:networks regulated by Toll-likereceptors mediate innate and adaptive immunity[J].Clin ExpImmunol,2007,147(2):199-207.
-
3李光照,杭春华.Toll样受体在脑损伤中的作用机制和研究进展[J].医学研究生学报,2010,23(12):1319-1323. 被引量:7
-
4Engel AL,Holt GE,Lu H.The pharmacokinetics of Toll-likereceptor agonists and the impact on the immune system[J].Expert Rev Clin Pharmacol,2011,4(2):275-289.
-
5Zeromski J,Mozer-Lisewska I,Kaczmarek M.Significance oftoll-like receptors expression in tumor growth and spreading:a short review[J].Cancer Microenviron,2008,1(1):37-42.
-
6Michelsen KS,Arditi M.Toll-like receptors and innateimmunity in gut homeost asis and pathology[J].Curr OpinHematol,2007,14(1):48-54.
-
7Zapata JM,Llobet D,Krajewska M,et al.Lymphocyte-specificTRAF3transgenic mice have enhanced humoral responsesand develop plasmacytosis,autoimmunity,inflammation,andcancer[J].Blood,2009,113(19):4595-4603.
-
8Sado T,Naruse K,Noguchi T,et al.Inflammatory patternrecognition receptors and their ligands:factors contributing tothe pathogenesis of preeclampsia[J].Inflamm Res,2011,60(6):509-520.
-
9Valins W,Amini S,Berman B.The expression of Toll-likereceptors in dermatological diseases and the therapeutic effectof current and newer topical Toll-like receptor modulators[J].J Clin Aesthet Dermatol,2010,3(9):20-29.
-
10Kanzler H,Barrat FJ,Hessel EM,et al.Therapeutic targe-ting of innate immunity with Toll-like receptor agonists andantagonists[J].Nat Med,2007,13(5):552-559.
二级参考文献16
-
1AN HuaZhang,QIAN Cheng & CAO XueTao National Key Laboratory of Medical Immunology & Institute of Immunology,Second Military Medical University,Shanghai 200433,China.Regulation of Toll-like receptor signaling in innate immunity[J].Science China(Life Sciences),2010,53(1):34-43. 被引量:29
-
2陈新忠,孙宗全,杜心灵,柳祎,吴龙,刘超,陈家军.单核细胞Toll样受体4可能介导热休克蛋白70信号的转导[J].中华医学杂志,2005,85(7):483-486. 被引量:17
-
3Gibson FC,Yumoto H,Takahashi Y,et al.Innate immune signaling and porphyromonas gingivalis-accelerated atherosclerosis[J].J dent Res,2006,85(2):106-121.
-
4Cario E,Podolsky DK.Toll-like receptor signaling and its relevance to intestinal inflammation[J].Ann N Y Acad Sci,2006,1072:332-338.
-
5Goepfert AR,Varner M,Ward K,et al.Differences in inflammatory cytokine and Toll-like receptor genes and bacterial vaginosis in pregnancy[J].Am J Obstet Gynecol,2005,193 (4):1478-1485.
-
6Lin Y,Zeng Y,Zeng S,et al.Potential role of toll-like receptor 3 in a murine model of polyinosinic-polycytidylic acid-induced embryo resorption[J].Fertil-Steril,2006,85(Suppl 1):1125-1129.
-
7Thornley TB,Brehm MA,Markees TG,et al.TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts[J].J Immunal,2006,176(3):1561-1570.
-
8Obhrai J,Goldstein DR.The roll of toll-like receptors in solid organ transplantation[J].Transplantation,2006,81(4):497-502.
-
9Romagne F.Current and future drugs targeting one class of innate immunity receptors:the Toll-like receptors[J].Drug Discov Today,2007,12(1-2):80-87.
-
10Ishihara S,Rumi MA,Ortega-Cava CF,et al.Therapeutic targeting of toll-like receptors in gastrointestinal inflammation[J].Curr Pharm Des,2006,12(32):4215-4228.
共引文献12
-
1张乐逸,张宇飞,嵇武.Toll样受体4的研究进展和临床意义[J].肠外与肠内营养,2009,16(2):123-126. 被引量:8
-
2欧红芹,马向华,沈捷,沈海军.白细胞介素6对人单核/巨噬细胞系细胞表面Toll样受体4表达的影响[J].南京医科大学学报(自然科学版),2010,30(3):319-323. 被引量:4
-
3张溢华,陈礼刚.Toll样受体4与动脉粥样硬化[J].重庆医学,2012,41(12):1223-1225. 被引量:3
-
4李伟,杭春华.CD24在生理与病理状态下的不同作用[J].医学研究生学报,2012,25(11):1201-1203. 被引量:1
-
5林克冰,葛辉,林琪,吴建绍,何丽斌,方琼珊,周宸.斜带石斑鱼TLR5S基因结构及功能分析[J].厦门大学学报(自然科学版),2013,52(1):109-115. 被引量:8
-
6伍宏亮,张青川.对TLR4的认识及其与前列腺癌研究进展[J].中华全科医学,2013,11(3):461-462. 被引量:3
-
7易世杰,赵礼金.TLR4及其作用的研究进展[J].蛇志,2013,25(2):183-187. 被引量:9
-
8李肖然,鲁晓擘.TLR4在KSHV感染的卡波西肉瘤中表达的研究进展[J].海南医学,2014,25(12):1787-1790. 被引量:4
-
9聂琪,孙绪德,王晋,张谅,李江静,张鸽.电磁脉冲对大鼠海马CA1区MyD88及JNK表达的影响[J].神经解剖学杂志,2018,34(6):710-714. 被引量:1
-
10梁桂娟,王迎涛,唐成和,刘艳红,关海山.Toll样受体4在新生大鼠缺氧缺血性脑损伤中的表达变化[J].中国新生儿科杂志,2016,31(3):222-225. 被引量:2
同被引文献36
-
1丁亮华,罗光华,董选.成人骨髓基质干细胞体外诱导成骨细胞[J].江苏医药,2005,31(2):84-86. 被引量:8
-
2喻本桐,马燕琳,刘季春,万于华,徐华.成人骨髓间充质干细胞多向分化潜能特性[J].江苏医药,2007,33(7):686-687. 被引量:3
-
3Glass GE,Chan JK,Freidin A,et al.TNF-αpromotes fracture repair by augmenting the recruitment and differentiation of muscle-derived stromal cells[J].Proc Natl Acad Sci USA,2011,108(4):1585-1590.
-
4Mountziaris PM,Mikos AG.Modulation of the inflammatory response for enhanced bone tissue regeneration[J].Tissue Eng Part B Rev,2008,14(2):179-186.
-
5Raicevic G,Najar M,Pieters K,et al.Inflammation and Toll-like receptor ligation differentially affect the osteogenic potential of human mesenchymal stromal cells depending on their tissue origin[J].Tissue Eng Part A,2012,18(13-14):1410-1418.
-
6Wennberg C,Hessle L,Lundberg P,et al.Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice[J].J Bone Miner Res,2000,15(10):1879-1888.
-
7Densmore JC,Signorino PR,Ou J,et al.Endothelium-derived microparticles induce endothelial dysfunction and acute lung injury[J].Shock,2006,26(5):464-471.
-
8Peek RM Jr, Crabtree JE. Helicobacter infection and gastric neopla- sia[J]. J Pathol, 2006, 208:233-248.
-
9Rothmeier AS, Ruf W. Protease-activated receptor 2 signaling in inflammation[J]. Semin Immunopathol, 2012, 34:133-149.
-
10Seo JH, Lim JW, Yoon JH, et al. Proteinase-Activated Receptor-2 Mediates the Expression of Integrin alpha5 and betal in Helieo- baeter pylori-Infected Gastric Epithelial AGS Cells[J]. Digestion, 2009, 80:40-49.
引证文献4
-
1陈奇,曹学书,朱华荣,王晓光,富仁杰,付海祥.Toll样受体4在干细胞成骨过程中的作用及机制[J].江苏医药,2015,41(18):2114-2116.
-
2俞敏,高璀乡,邱静.PAR2参与幽门螺杆菌致病机制的研究进展[J].北京医学,2015,37(10):987-989. 被引量:1
-
3袁明明,任晓燕,谢慧君,王伟伟,陈莉.Toll样受体3在原发性肝细胞癌中的表达及其与细胞凋亡、血管生成的相关性[J].江苏医药,2018,44(3):256-259. 被引量:3
-
4韩超,金婧,刘婷婷.TLR配体对小鼠HPV11E7基因CTL表位肽的免疫调节作用[J].医学临床研究,2018,35(8):1554-1556.
二级引证文献4
-
1郝建云,马昕,宁慧娟,宫幼喆,朱丹,王美娟,金萌,廖伟伟,郝春娟,孙艳香,张艳玲,钟雪梅.3352例儿童经胃镜检查幽门螺杆菌感染分析[J].北京医学,2020,42(2):95-98. 被引量:5
-
2黄珊珊,陈昕.宫颈癌组织中AEG-1和TLR3表达与其微血管密度及预后的相关性[J].中国临床研究,2020,33(10):1391-1395. 被引量:5
-
3张宇,刘雪涛.Toll样受体3活化对人脐静脉内皮细胞凋亡的影响及其机制[J].新乡医学院学报,2022,39(8):715-720.
-
4律颖,袁朋瑞,徐敬轩.较低级别胶质瘤坏死性凋亡相关基因的筛选与功能分析[J].肿瘤代谢与营养电子杂志,2023,10(2):213-218.
-
1李蓓,王敏.Th17细胞的分化与调节[J].现代免疫学,2009,29(5):431-434. 被引量:13
-
2李淮岗,贺明盟,铁宝娴,王娟,王琪.间质反应在乳腺良恶性病变中的意义[J].中国基层医药,2001,8(5):437-437. 被引量:1
-
3贾蓓,钱元恕.中性粒细胞在细菌感染中的免疫调节作用[J].国外医药(抗生素分册),2004,25(2):61-63. 被引量:12
-
4程千松,王兴兵,汪健,虞国慧.Toll样受体激动剂对骨髓间充质干细胞成骨及成脂分化的影响[J].安徽医学,2015,36(1):1-4. 被引量:1
-
5肖慧捷,徐可,丁洁.补体在儿童免疫和/或炎症性肾脏疾病中的新认识[J].临床儿科杂志,2015,33(6):504-510.
-
6李蓓,王敏.CD4^+T细胞的新成员:Th17细胞[J].生命的化学,2009,29(2):172-175. 被引量:15
-
7孟忠吉,张永红,李文兵,汤守兵,李东,柯昌征,陈悦.Toll样受体激动剂抑制土拨鼠肝炎病毒作用研究[J].肝脏,2013,18(6):378-381. 被引量:5
-
8李晓敏,张燕楠,杨滨燕,吴长有.不同Toll样受体激动剂对小鼠辅助性T细胞功能的影响[J].细胞与分子免疫学杂志,2015,31(11):1441-1446.
-
9曾祥兴,张驰,李康生.无脊椎动物细胞免疫研究进展[J].国际免疫学杂志,2009,32(5):354-358. 被引量:4
-
10范丽莉,刘翠青.新生儿红细胞免疫功能的研究进展[J].河北医药,2010,32(15):2099-2101. 被引量:3