妊娠高血压综合征患者血管内皮生长因子的变化及其意义

Changes and Significance of Concentrations of Serum Vascular Endothelial Growth Factor in Patients with Pregnancy Induced Hypertension

目的 检测妊娠高血压综合征 (妊高征 )患者外周血中血管内皮生长因子 (VEGF)的水平 ,并探讨其与妊高征发病的关系。方法 应用双抗体酶联免疫吸附法 (ELISA)检测未妊娠妇女 (正常组 ,2 3例 )、正常妊娠妇女 (妊娠组 ,30例 )以及妊高征患者 (妊高征组 ,37例 )外周血中VEGF的水平。结果 ( 1 )与正常组的 ( 1 1 .98± 3.99)ng/L相比 ,妊娠组VEGF水平明显上升 ,为 ( 1 49.39± 2 7.1 5 )ng/L ,两组比较 ,差异有极显著性 (P <0 .0 0 1 ) ;妊娠组至孕中期VEGF水平达高峰 ,为 ( 1 83.84± 49.0 2 )ng/L ,至孕晚期开始下降 ,为 ( 1 1 8.37± 34 .2 9)ng/L。 ( 2 )妊高征组VEGF水平 ( 6 4 .45± 2 4.33)ng/L ,明显低于妊娠组孕晚期水平 (P <0 .0 1 ) ,并随妊高征病情的加重 ,VEGF水平呈逐渐下降趋势 (P <0 .0 5 )。结论 妊娠后VEGF水平显著下降可能是妊高征发病机理中的一个重要因素。

Objective To detect the changes of concentrations of serum vascular endothelial growth factor (VEGF) in patients with pregnancy induced hypertension (PIH) as well as to explore the relationship between VEGF and pathogenesis of PIH. Methods Serum VEGF concentrations in 23 healthy nonpregnant women (nonpregnant group),30 normal pregnant women (normal pregnancy group) and 37 women with PIH (PIH group) were measured by sandwich enzymelinked immunoadsorbent assay (ELISA). Results Serum concentrations of VEGF were significantly higher in normal pregnancy group (149.39±27.15) ng/L than those in nonpregnant group (11.98±3.99) ng/L (P<0.001),peaking in the second trimester of pregnancy (183.84±49.02)ng/L and decreasing in the third trimester (118.37±34.29)ng/L. Serum VEGF concentrations (64.45±24.33)ng/L in PIH group were significantly lower than those in normal late pregnancy group (118.37±34.29)ng/L (P<0.01).There was a trend that serum VEGF concentrations in PIH group decreased with the severity of PIH (P<0.05). Conclusion The decrease of VEGF may play an important role in the pathogenic mechanism of PIH.