慢性乙型肝炎、肝硬化、肝癌患者血清IL-8、IL-10和leptin水平变化及其临床意义

Clinical Significance of Changes on Serum Levels of IL-8,IL-10 and Leptin in Patients with Chronic Hepatitis B(CHB),Liver Cirrhosis(LC)and Primary Hepatocellular Carcinoma(PHC)

目的:探讨慢性乙型肝炎、肝硬化、肝癌患者血清IL-8、IL-10和leptin水平的变化及其临床意义。方法:应用放射免疫分析测定35例慢性乙型肝炎、30例肝硬化、27例肝癌患者的血清IL-8、IL-10和leptin水平,并与正常对照组比较。结果:各组患者的血清IL-8、IL-10和leptin水平均较正常对照组显著地增高,相关分析的数据表明,血清leptin水平与IL-8呈正相关。结论:血清IL-8、IL-10和leptin水平的变化与慢性乙型肝炎、肝硬化、肝癌发生发展密切相关。

Objective To explore the clinical significance of changes on serum levels of interleukin-8 （IL-8）, interleukin-10 （ IL- l0） and lepfin（LEP） in patients with chronic hepatitis B （CHB）, liver cirrhosis （LC） , primary hepatocellular carcinoma （PHC）. Methods The levels of serum IL-8, IL-10 and leptin were detected by RIA in 35 patients with CHB ,30 patients with LC ,27 patients with PHC as well as 30 health control respectively. Results The levels of IL-8, IL-10 and leptin in CHB, LC, and PHC groups were dramatically higher than those in control group （ P 〈 0.01 ）. Correlation analysis of data proclaimed that level of leptin correlated posi- tively with level of IL-8 in patients （P 〈 0.01 ）. Conclusion The changes of serum levels of IL-8, IL-10 and lepfin may play a cer- tain role in occurrence and development of CHB, LC, and PHC.