氟伐他丁对CHD患者血清Hcy、IL-6和IL-8水平的影响

Effect of Fluvastatin on Serum Hcy,IL-6 and IL-8 Levels in Patients with Coronary Heart Disease(CHD)

目的:探讨了氟伐他丁对冠心病(CHD)患者血清Hcy、IL-5和IL-8水平的影响。方法:采用随机、对照的方法将88例CHD患者分为氟伐他丁组(35例)和常规治疗组(53例)。另选50例健康人作为正常对照组。测定治疗前、治疗后2个月血清Hcy、IL-6和IL-8的变化。结果:①CHD患者血清Hcy、IL-6和IL-8水平非常显著地高于正常人组(P<0.01);②氟伐他丁组治疗2个月后血清Hcy、IL-6和IL-8水平非常显著地降低(P<0.01),而常规治疗组治疗后则无显著性变化。结论:氟伐他丁对CHD患者具有抗炎治疗作用。

Objective To study the effect of fluvastatin on changes of serum Hcy, IL-6 and IL-8 levels in patients with coronaryheart disease. Methods 88 patients with CHD were random in divided into fluvastatin-treated group（35cases） and conventional thera- py group （53cases）. In addition, 50 healthy persons served as control group. Serum IL-6, IL-8 （with RIA） and Hcy（with ELISA） lev- els were measured both before and after treatment for 2 months with fluvastatin in these CHD patients as well as in controls. Results ①Before treatment,the levels of serum Hcy, IL-6, IL-8 were remarkably higher in the patients with CHD than those in controls （P 〈 0. 01 ）. ② After treatment, the levels of serum Hcy, IL-6, IL-8 in patients with fluvastatin-treated group decreased significantly （P 〈 0. 01 ）, but the levels were not much changed in the conventional therapy group. Conclusion Fluvastatin have anti-infammatory and therapeutic effect on the patients with CHD.