急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8检测的临床意义

Clinical Significance of Determination of Changes of Plasma Leptin and Serum hs-CRP,IL-6 and IL-8 Levels in Patients with Acute Pancreatitis

目的:探讨了急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平的变化及临床意义。方法:应用放射免疫分析和免疫比浊法对30例急性胰腺炎患者进行了血浆leptin和血清hs-CRP、IL-6和IL-8检测,并与35名正常健康人作比较。结果:急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平均非常显著地高于正常人组(P<0.01)且急性胰腺炎患者血浆leptin和血清hs-CRP、IL-6和IL-8水平呈正相关(r=0.6132、0.5786、0.6218,P<0.01)。结论:检测急性胰腺炎患者血浆leptin与血清hs-CRP、IL-6和IL-8水平的变化对观察病情发展及预后判断均有重要的临床价值。

Objective To explore the clinical significance of Determination of changes of plasma leptin and serum hs-CRP, IL-6, IL-8 levels in patients with acute pancreatitis. Methods Plasma leptin, serum IL-6,IL-8 （with RIA） and serum hs-CRP（with immu- no-turbidity method） levels were measured in 30 patients with acute pancreatitis and 35 controls. Results Plasma leptin and serum hs-CRP, IL-6, IL-8 levels were significantly higher than those in controls （P 〈 0.01 ）. Plasma leptin level was positive correlated with serum hs-CRP,IL-6,IL-8 （r=0. 6132,0.5786,0.6218,P〈0. 01）. Conclusion Detection of plasma leptin and serum hs-CRP, IL- 6, IL-8 levels is clinically useful to monitoring progress and prognosis in patients with acute pancreatitis.