摘要
目的:探究血浆氨基末端B型尿钠肽前体(NT-proBNP))在慢性充血性心力衰竭(CHF)患者中的诊断价值。方法:采用单克隆非均相免疫法在德灵自动化仪器上检测79例CHF患者和42例正常对照组血浆中NT-proBNP水平,并进行统计学分析。结果:CHF患者血浆NT-proBNP水平明显高于正常对照组(P<0.01),差异有统计学意义,且心衰组血浆NT-proBNP水平与病情严重程度呈正相关(P<0.01)。结论:血浆NT-proBNP水平可以作为CHF患者的实验室诊断指标,用于临床诊断、治疗及评估严重程度的辅助方法。
Objective To explore diagnostic value of the plasma amino-terminal B-type natriuretic peptide （NT-proBNP）） in pa- tients with chronic congestive heart failure （CHF）. Methods Plasma NT-proBNP level was masured in 79 cases of CHF patients, as well as in 42 normal healthy controls. Plasma heterogeneous immunoassay using Dade Behring automatic instrument. Results Plas- ma NT-proBNP level in CHF patients was significantly higher than that in control group （P 〈0.01 ）, the difference was statistically sig- nificant. NT-proBNP level in sera of heart failure group has positive correlation with severity degree of disease （ P 〈 0.01 ）. Conclu- sion Plasma NT-proBNP level can be used as a marker of laboratory diagnosis of CHF patients and an auxiliary method for treatment and assessment the severity degree of disease.
出处
《放射免疫学杂志》
CAS
2012年第2期173-175,共3页
Journal of Radioimmanology
关键词
非均相免疫法
氨基末端B型尿钠肽前体
慢性充血性心力衰竭
急性心肌梗死
heterogeneous immunoassay, amino-terminal B-type pronatriuretic, peptide, chronic congestive heart failure（CHF）, acute myocardial infarction（AMI）
