依那普利治疗原发性高血压对血浆NO、vWF的影响

The Influence of Enalapril on Plasma Nitric Oxide and Von Willebrand Factor in the Treatment of Essential Hypertension

目的:评价依那普利治疗轻、中度原发性高血压对一氧化氮(NO)、内皮血管性血友病因子(vWF)的影响。方法:选取轻、中度原发性高血压患者45例及正常对照组30例,原发性高血压组服用依那普利20mg/d,分别对治疗前、治疗16周后及正常对照组行血浆NO、vWF检测。结果:治疗前血浆NO较正常对照组降低(P<0.05),治疗后血浆NO较治疗前明显升高(P<0.01)。治疗前血浆vWF较正常对照组明显升高(P<0.01),治疗后血浆vWF较治疗前降低(P<0.05)。结论:依那普利明显升高血浆NO、降低vWF,说明它在降压的同时具有保护血管内皮细胞的功能。

Objective To evaluate the effects of Enalapril on plasma nitric oxide and yon Willebrand factor （ vWF ） in treating the patients with grade 1 or grade 2 essential hypertension. Methods 45 cases of patients with grade 1 or grade 2 essential hyperten- sion and 30 normal persons were served as control. The hypertension group was treated with Enalapril 20mg,/d. Both plasma NO and vWF were tested both before and after treatment for 16 weeks. Results The plasma NO before treatment in the essential hypertension group decreased significantly than that in normal group （ P 〈 0.05 ） and plasma NO after treatment raised obviously than that before treatment （P 〈0.01 ） . The plasma vWF before treatment in the essential hypertension group raised distinctly than that in group（P 〈 0.01 ） and plasma vWF after treatment decreased than that before treatment （ P 〈 0.05 ）. Conclusion Enalapril raises plasma NO and decreases plasma vWF significantly. It is shown that Enalapril not only reduces hypertension but also protects function of vascular endothelial cells .