MCP-1及IL-10在狼疮性肾炎及其相关疾病活动度的临床意义

Clinical Significance of Monocyte Chemoattractant Protein-1 and Intedeukin-10 in Patients with Lupus Nephritis and its Correlation with Disease Activity

目的:分析活动期和静止期狼疮性肾炎(LN)患者血清和尿液标本中单核细胞趋化蛋白-1(MCP-1)和IL-10水平的变化并探讨其临床意义。方法:应用ELISA技术对活动期和静止期LN患者血清和尿液中MCP-1和IL-10进行检测,分析LN不同时期MCP-1和IL-10与其他相关指标之间的关系。结果:活动期患者尿液MCP-1水平显著地高于静止期患者,而血清MCP-1两者差异无统计学意义;活动期患者血清IL-10水平显著地高于静止期患者,而尿液IL-10两者差异无统计学意义。结论:尿液MCP-1和血清IL-10水平可能与LN活动存在一定的相关性,有望成为SLE肾脏损害及疗效观察的监测指标。

Objective To determine the change level in the serum and urine of MCP-1 and IL-IO of patients with lupus nephritis （LN） who are at aetive and resting stage as well as the two indicators clinical significance. Methods Serum and urine concentrationof MCP-land IL-IO were detected by enzyme-linked immunosorbent assay （ELISA） and their relations to other related indicators at dif- ferent stages were studied. Results Urine concentration of MCP-1 in active patients with lupus nephritis was significantly higher than that in resting ones, but there was no difference in serum. Serum concentration of IL-IO in active patients with lupus nephritis was ob- viously higher than that in resting ones, but there was no difference in urine. Conclusion The concentration of urine MCP-1 and ser- um IL-IO may have a certain correlation with lupus nephritis, it may be a useful parameter for monitoring of kidney damage and monito- ring the efficacy of treatment.