妊高征肾病患者血清CysC水平与红细胞膜ATP酶活性的关系

Relationship Between Serum CysC Level and ATPase Activity of Erythrocyte Membrance in Patients with Pregnancy Induced Hypertension(PIH)Complicating Nephropathy

目的:探讨了妊高征肾病患者血清胱抑素蛋白酶抑制素C(CysC)水平与红细胞膜Na^+、K^+-ATP酶和Ca^(2+)、Mg^(2+)-ATP酶活性改变参与妊高征肾病发生的可能机制。方法:应用乳胶免疫增强比浊法和Reinil制膜法测定了32例妊高征肾病患者血清CysC水平与红细胞膜Na^+、K^+-ATP酶和Ca^(2+)、Mg^(2+)-ATP酶含量,并与35名正常孕妇组作比较。结果:妊高征肾病患者血清CysC水平非常显著地高于正常孕妇组(P<0.01),而红细胞膜Na^+、K^+-ATP酶和Ca^(2+)、Mg^(2+)-ATP酶含量显著地低于正常孕妇组(P<0.01)。结论:妊高征肾病的发生发展与血清CysC水平和红细胞膜Na^+、K^+ATP酶和Ca^(2+)、Mg^(2+)-ATP酶活性有密切的关系。

Objective To study the possible mechanism of development of nephrosis affected by changes of serum CysC levels and alteration of activities of Na^＋-K^＋ -ATPase and Ca^2 ＋ -Mg^2＋ -ATPase of erythrocyte membrance in patients with pregnancy induced hypertension complicating nephropathy. Methods Serum CysC （with latex-enhanced irmnunoturbidimetry） and erythrecyte membrance Na^＋ -K^ ＋ -ATPase and Ca^2＋ -Mg^2＋ -ATPase activities （with reinila method） levels were determined in 32 PIH complicating nephropathy and 35 normal healthy controls. Results Serum CysC level was significantly higher in the patients with PIH complicating nephropathy as a whole than that in controls （P 〈0.01 ）. While the RBC Na^＋ -K^＋-ATPase and Ca^2＋ -Mg^2＋ -ATPase activities were obviously lower （P 〈 0.01 ）. Conclusion Development of PIH complicating nephropathy might be correlated with the high serum CysC levels and de- creased ATPase activities of erythrocyte membrance.