摘要
本文报道在八名健康志愿者中进行氟啶酸药物代谢动力学研究的结果。该药的体内过程符合单室模型,单剂空腹口服该药的片、胶囊和原粉400mg后的平均峰浓度、达峰时间及药时曲线下面积分别为3.06～3.22mg/l,1.18～1.8h和16.10～19.25mg/1·h;其消除半衰期为4.15～4.82h,表观分布容积为157.3～210.71。氟啶酸自尿中排出给药量的51.20～54.66%。基于上述药代动力学参数及其抗菌活性拟订了用于治疗各种感染的给药方案。
Clinical pharmacokinetic study on enoxacin was carried out in 8 normal volunteers. The drug obeyed one-compartment model kenetics in serum. The mean peak serum concentration, time to peak concentration and the area under the curve were 3.06-3.22 mg/1, 1. 18-1. 8h and 16. 10-19.25mg/1. h respectively after oral administration of 400mg enoxacin tablet, capsule and powder. The elimination half life and the apparent volume of distribution ranged from 4. 15 to 4. 82h and 157. 3 to 210. 71. The urinary recovery rate of enoxacin over 24h after dosing was morethan 50%, ranged from 51. 20-54. 60%. Based on its pharmacokinetic characteristics and antimicrobial activity,a therapetic regimen is suggested for use in the treatment of various infec-tions.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1990年第4期231-234,共4页
The Chinese Journal of Clinical Pharmacology
关键词
氟啶酸
药代动力学
抗菌药
enoxacin
pharmacokinetics
therapeutic regimen
