大肠癌组织中类固醇激素受体与淋巴结转移及预后的相关性

The relativity of steroid hormone receptor in tissue of large intestine carcinoma with lymphatic metastasis and prognosis

目的 研究大肠癌组织中类固醇激素受体与淋巴结转移及预后的相关性。方法 应用免疫组化ABC法检测99例大肠癌组织中的类固醇激素受体。结果 大肠癌组织中有类固醇激素受体表达,其中ER、PgR、AR阳性率分别为32.2%、38.4%、30.3%,类固醇激素受体阳性率与组织学分化程度成正相关,且类固醇激素受体阳性患者淋巴结转移率低,预后好。结论 类固醇激素受体在反映淋巴结转移率及预后方面与组织学分化程度有一致性。

Objective To explore the relativity of steroid hormone receptor (SHR) in the tissue of large intestinal carcinoma with lymphatic metastasis and prognosis.Method 99 cases of carcinoma of large intestine were examined by the immunohistochemical ABC method.Results The positive rates of ER,PgR and AR were 32.3%,38.3% and 30.3% respectively,and there was a direct correlation between the histological degree of differentiation and positive rate of SHR.Those whose SHR was positive had a lower rate of lymphnode metastasis and a better prognosis.Conclusion The result showed that expression of SHR in the tissue of large intestinal carcinoma reflects the lymphatic metastasis and prognosis just in concordance with that of histochemically differentiating degree.