缓作用药在强直性脊柱炎治疗中的地位

Efficacy of slow acting antirheumatic drugs in ankylosing spondylitis

目的 探讨柳氮磺吡啶(SSZ)、雷公藤多甙(T2)、甲氨蝶呤(MTX)等缓作用抗风湿药在强直性脊柱炎(AS)治疗中的地位。方法 追踪230例AS0.5～8a治疗情况,观察其临床、实验室及影像学等方面的变化。结果 单独和联合用药均可使临床和实验室指标得到改善,部分病人骶髂关节炎得到控制甚至改善;髋关节受累者骶髂关节炎较重。结论 SSZ、T2、MTX均对AS有效,SSZ对中轴型AS也有效,联合用药可提高疗效;AS治疗应在3a以上;髋受累是病情严重性及预后不良的指标之一。

Objective The efficacy of slow acting antirheumatic drugs (SAARDs) including sulfasalazine (SSZ),tripterygium glycosides (T2),methotrexate (MTX) in ankylosing spondylitis (AS).Methods Reviewed the variables of clinical,laboratory and radiographic data in 230 patients with AS within 0.5～8 years.Results Both single and combined drug therapy were of benefit to the clinical and laboratory indices.Some patients got relief from sacroiliitis.Hip involvement was associated with the disease severity.Conclusion SSZ,T2,MTX are all effective on AS.SSZ is good to axial AS as well as peripheral AS;the combined therapy could improve the efficacy.Treatment of AS must last more than three years.Hip involvement indicates the severity and bad prognosis.