儿童尿路感染的病原菌分布及耐药现状调查分析

Constituent ratio and antimicrobial resistance of pathogenic bacteria causing urinary tract infections in children

目的调查了解儿童尿路感染的常见病原菌分布及耐药性,为临床医师合理使用抗菌药物提供科学的参考依据。方法对2008年1月-2010年12月医院患儿中段尿标本培养的病原菌药敏结果进行统计分析。结果115株儿童尿路感染病原菌以大肠埃希菌和肠球菌属为主,分别占40.0%、17.4%;所有病原菌对常用抗菌药物均显示了不同程度的耐药性,革兰阴性杆菌仅对亚胺培南、美罗培南100.0%敏感,革兰阳性球菌对万古霉素、替考拉宁100.0%敏感。结论儿童尿路感染病原菌分布与成年人相似,耐药性呈上升趋势,应采取有效措施控制细菌耐药性的快速增长。

OBJECTIVE To investigate the constituent ratio and antimicrobial resistance of pathogenic bacteria causing urinary tract infections in children and provide the reference for clinically reasonable use of antibiotics. METHODS The strains isolated from urine specimens from Jan. 2008 to Dec. 2010 were recruited in this study. The positive results of urine culture were statistically analyzed. RESULTS Among 115 isolates, the majority was Escherichia coli and Enterococci which accounted for 40. 0% and 17. 4%, respectively. Except for 100. 0%susptibility rate of imipenem and meropenem to gram-negative bacilli and of vancomycin and teicomycin to grampositive cococci, pathogenic bacteria were resistant to the most commonly used antibiotics in varying degree. CONCLUSION The constituent ratio of pathogenic bacteria from children was similar to adults. The antimicrobial resistance was rising. We should take effective measures to control the increasing tendency of antimicrobial resistance.