金黄色葡萄球菌对莫匹罗星高水平耐药的研究

High-level resistance of Staphylococcus aureus to mupirocin

目的了解金黄色葡萄球菌(SAU)对莫匹罗星高水平耐药(MUH)的状况,并探讨其耐药菌株对临床常用抗菌药物的耐药特性。方法用美国BD公司Phoenix-100型全自动细菌鉴定药敏系统鉴定细菌及做药敏试验,该仪器可以同时检测耐甲氧西林金黄色葡萄球菌(MRSA)和莫匹罗星高水平耐药的金黄色葡萄球菌。结果共检出金黄色葡萄球菌382株,其中MUH菌株检出25株,检出率为6.5%,其中23株为MRSA,占92.0%;莫匹罗星高水平耐药的金黄色葡萄球菌对阿米卡星等15种临床常用抗菌药物耐药率较高,均>80%,且呈多药耐药,但对万古霉素、利奈唑胺全部敏感,呋喃妥因耐药率也较低。结论临床分离的金黄色葡萄球菌中,已出现莫匹罗星高水平耐药的菌株,临床应加强对该类菌株的监测,以减少耐药菌株的产生和流行。

OBJECTIVE To investigate the status of highlevel resistance of Staphylococcus aureus （SAU） to mupirocin and the resistance of mupirocinresistant strains to commonly used antibiotics. METHODS The identification of bacteria and drug susceptibility test were performed with Phoenixi00 fullautomatic system. The system could detect both methicillinresistant S. aureus （MRSA） and highlevel mupirocinresistant S. aureus at the same time. RESULTS Totally 382 SAU strains were obtained, in which 25 isolates （6.5 %） were highlevel mupirocinresistant （MUH）. Among 25 highlevel mupirocinresistant strains, 23 strains were methicillin resistant S. aureus （MRSA）, accounting for 92.0%; the drug resistance rates of highlevel mupirocinresistant SAU to amikaein and other common antibiotics were relatively high, which were all over 80. 0%. They were multidrugresistant, however, all the strains were susceptible to vancomycin and linezolid. The resistance rate to nitrofurantoin was low. CONCLUSION Of the clinical isolated SAU, highlevel mupirocinresistant strains have emerged, therefore, the monitoring of highlevel mupirocinresistant SAU isolates should be strengthened in clinical practice in order to prevent it from generation and dissemination.