2006-2010年鲍氏不动杆菌的耐药性分析

Drug resistance of Acinetobacter baumanii from 2006 to 2010

目的了解医院鲍氏不动杆菌的耐药性变迁,为临床合理使用抗菌药物及控制医院感染提供依据。方法对2006-2010年临床分离的625株鲍氏不动杆菌,用纸片扩散法检测其对头孢他啶等13种抗菌药物的耐药率。结果收集的625株鲍氏不动杆菌中,鲍氏不动杆菌对头孢哌酮/舒巴坦、亚胺培南、美罗培南的耐药率均≤40.0%,分别为27.7%、37.3%、40.0%,对阿米卡星、哌拉西林/他唑巴坦、头孢吡肟的耐药率约为60.0%;对环丙沙星、磺胺甲噁唑/甲氧苄啶、哌拉西林、头孢曲松的耐药率均>70.0%,分别为71.2%、72.6%、77.0%、81.1%;2009年以来全耐药鲍氏不动杆菌迅速增加。结论医院临床分离的鲍氏不动杆菌耐药率高,临床上应根据药敏结果合理选用抗菌药物。

OBJECTIVE To investigate the change of drug resistance of Acinetobacter baumanii （ABA）, so as to provide reference for the rational clinical application of antibacterials and the control of nosocomial infections. METHODS A total of 625 strains of ABA were collected from 2006 to 2010. The drug resistance to 13 antibacteri als including ceftazidime was detected by disk diffusion method. RESULTS The resistance rates of the 625 strains ofABA to cefoperazone/sulbactam, imipenem, and meropenem were less man 40.0%, wmcu welc 27.7%,37.3 %, and 40%, respectivelyl those to amikaein, piperacillin/tazobactam, and c（ffepime were around 60.0%; those to eiprofloxacin, SMZ/TMP, piperacillin, and cetriaxone were higher than 70.0%, whiLch were 71.2%, 72.6 %, 77. 0V0, and 81. 1%, respectively. Since 2009, pandrugresistant ABA isolates have been increasing rapidly. CONCLUSION The drug resistance rate of the clinical ABA isolates is high, and antibiotics should be chosen according to drug susceptibility test in the clinical practice.