手术前后皮肤组织KGFmRNA表达量的变化

Differential expression of mRNA keratinocyte growth factor in the skin before and after the operation

目的 探讨创伤后组织修复的机理。方法 在术中和术后 2 4小时采集皮肤 12组 ,抽提总RNA ,用RFPCR法检测术前术后皮肤组织中KGF表达量的变化。结果 发现术后 2 4小时皮肤组织中KGFmRNA表达量显著增高。结论 DGF表达增多在创伤后皮肤修复中起着重要的作用。

Objective To study the mechanism in wound repair. Methods We took 12 pairs of skin preparations during operation and 24 hours after operations, extracted total RNA, and analyzed keratinoyte growth factor expression by RTPCR. Results The level of KGF mRNA expression was predominantly higher 24 hours after skin injury. Conclusion High level of KGF plays an important role in wound repair.