糖化血红蛋白检测对非糖尿病高血压患者的临床价值

Clinical value of HbA1c test in patients with non-diabetic hypertension

目的探讨糖化血红蛋白检测对非糖尿病高血压患者的临床价值。方法对268例原发性高血压但未诊断糖尿病住院患者进行三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、空腹胰岛素(Fins)和糖化血红蛋白(HbA1c)检测,同时以243例健康人血标本为健康对照组,检测同样项目并与高血压组进行对比分析。结果高血压组和健康对照组之间的TG、TC、HDL、LDL和FPG水平差异无统计学意义(P>0.05);高血压组的Fins和HbA1c水平分别为(8.24±4.55)mU/L、6.92%±1.83%,健康对照组分别为(6.74±3.98)mU/L、5.07%±0.81%,差异有统计学意义(P<0.05);Ⅰ级高血压组的HbA1c为6.43%±1.55%,Ⅱ级高血压组为6.95%±1.67%,Ⅲ级高血压组为7.32%±1.76%,差异有统计学意义(P<0.05)。结论 HbA1c水平与非糖尿病高血压患者有密切关系,是原发性高血压的危险因素。

Objective To investigate the clinical value of HbAlc test in the patients with non-diabetic hyper tension. Methods 268 cases of nowdiabetic hypertension were selected. The level of TG, TC, HDL, I.DL, FPG, Fins and HbAle were examined. The same tests were examined in the control group of 243 cases of normal blood samples to compare with the hypertension group. Results No significant differences in the average levels of TG, TC, HDL, LDL and FPG were found between the hypertension group and the control group（P〉0.05）. There were significant differences in Fins and HbAlc level between the hypertension group and the control group（8.24± 4.55） mU/L,6.92%±1.83G vs. （6.74±3. 98）mU/L, 5. 07G--0. 81%,P〈0. 05）. Also, significant differences in HbAlc level was found among the hypertension group I, hypertension group Ⅱ and hypertension group Ⅲ （6.43% ± 1.55%, 6.95%±1.67%, 7.32%± 1.76 %, P〈0.05）. Conclusion HbA1 c level is closely related with non diabetic hypertension and is a risk factor for primary hypertension.