乳腺癌患者手术治疗前后血清肿瘤标志物联合测定的临床意义

Clinical significance of joint detection of serum tumor markers before and after operation in patients with breast cancer

目的联合检测乳腺癌患者手术治疗前后血清中肿瘤相关抗原153(CA153)、癌胚抗原(CEA)、恶性肿瘤特异性生长因子(TSGF)含量的变化,探讨其在复发监测中的临床价值。方法用电化学发光法和生化比色法对45例乳腺癌患者进行了手术治疗前后血清CA153、CEA及TSGF含量检测,并与31例健康对照组作比较。结果乳腺癌患者手术前血清CA153、CEA、TSGF水平分别为(46.91±43.87)U/mL、(16.26±15.86)μg/L、(76.60±41.92)U/mL,健康对照组分别为(14.32±3.28)U/mL、(5.05±2.07)μg/L、(51.94±27.83)U/mL,差异有统计学意义(P<0.01),3个月后降至健康对照组水平(P>0.05)。手术切除1年后复发者血清CA153、CEA、TSGF水平持续异常,未复发者基本接近正常。结论检测血清CA153、CEA、TSGF的水平与乳腺癌患者的病情和预后密切相关,具有一定的临床实用价值。

Objective To investigate the clinical significance of the changes of serum CA153,CEA and TSGF levels before and after operation in the patients with breast cancer. Methods Serum CA153,CEA,TSGF were measured with the electrocbemiluminescence and biochemical colormetric methods before and after surgery in 45 patients with breast cancer as well as in 31 healthy controls. Results Before operation,serum CA153,CEA and TSGF levels were （46.91±43.87）U/mL,（16.26±15.86）μg/L and（76.60±41.92）U/mL in breast cancer group,which in the control group were （14.32±3.28）U/mL,（5.05±2.07）μg/L and（51.94±27.83）U/mL respectively, showing sta- tistical difference（P〈0.01）. The levels in breast cancer group were dropped to normal level in three months after op- eration（P〉 0.05）. In one year after operation the levels of serum CA153, CEA, TSGF in the patients with recurrence were abnormally high again, while the levels in the patients without recurrence were basically approach to normal. Conclusion The detection levels of serum CA153,CEA and TSGF are closely related to the disease status and prog- nosis in the patients with breast cancer and possess certain clinical practical value.