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重组人促红细胞生成素对颅脑创伤患者血清NSE、S-100β及IL-10的影响 被引量：2

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摘要 目的探讨重组人促红细胞生成素(R-huEPO)对颅脑创伤患者血清NSE、S-100β、IL-10的影响。方法纳入40例颅脑创伤患者,随机分为治疗组和对照组各20例,均给予常规颅脑创伤治疗,治疗组在此基础给予R-huEPO皮下注射治疗,比较两组治疗后的外周血清NSE、S-100β、IL-10含量及格拉斯哥昏迷(GCS)评分。结果治疗组GCS评分较治疗前显著升高(P<0.01)并高于对照组(P<0.05);治疗组血清NSE、S-100β含量显著降低且低于对照组(P<0.05),血清IL-10含量降低而程度小于对照组(P<0.05);外周血清NSE、S-100β含量与GCS评分呈负相关。结论 NSE、S-100β及IL-10与颅脑创伤患者的神经损害密切相关。R-huEPO可抑制过度炎症反应,减轻颅脑创伤患者继发病理损伤,具有神经保护作用。
作者 潘轲 邓民强 刘浏
机构地区 恩施自治州中心医院神经外科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第1期163-165,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 颅脑损伤 红细胞生成素 重组 神经元特异性烯醇化酶 S100蛋白质类 白细胞介素10
分类号 R651.15 [医药卫生—外科学]
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共引文献17

同被引文献29

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中华临床医师杂志（电子版）
2012年 第1期

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