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肿瘤坏死因子样弱凋亡诱导因子在强直性脊柱炎患者血浆中的表达及临床意义 被引量：3

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摘要 目的通过检测强直性脊柱炎(AS)患者血浆中肿瘤坏死因子样弱凋亡诱导因子(TWEAK)的表达情况,探讨其在AS发病机制中的作用及临床意义。方法采用酶联免疫吸附试验(ELISA)检测46例AS患者及32例健康对照者血浆中TWEAK及TNF-α水平,分析TWEAK与AS的各项临床及实验室指标的相关性。结果 AS患者血浆TWEAK水平[(504.82±121.54)pg/ml]与健康对照组[(475.64±79.31)pg/ml]相比无统计学差异,但疾病活动期AS患者血浆中TWEAK水平[(521.93±85.36)pg/ml]比健康对照组高,差异有统计学意义,相关性分析结果显示疾病活动期AS患者血浆TWEAK水平与TNF-α水平呈正相关(r=0.437,P=0.033),与C反应蛋白(CRP)、红细胞沉降率(ESR)水平无明显相关。结论血浆TWEAK水平可能与AS疾病活动有一定关系,参与了AS的炎症反应过程。
作者 杨婧 帅世全 刘剑平 孙红兵
机构地区 四川省南充市中心医院(川北医学院第二临床学院)风湿免疫科 四川省南充市川北医学院附属医院风湿血液科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第3期172-173,共2页 Chinese Journal of Clinicians(Electronic Edition)
关键词 脊柱炎 强直性 肿瘤坏死因子Α 肿瘤坏死因子样弱凋亡诱导因子
分类号 R593.23 [医药卫生—内科学]
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  • 1Huber LC, Distler O, Tarner I, et al. Synovial fibroblasts; keyplayers in rheumatoid arthritis [ J ]. Rheurnatology ( Oxford), 2006, 45 ( 6 ) : 669 - 675.
  • 2Chicheportiche Y, Chicheportiche R, Sizing I, et al. Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies [J]. Arthritis Res, 2002, 4(2) : 126 -133.
  • 3Kamijo S, Nakajima A, Kamata K, et al. Involvement of TWEAK/ Fn14 interaction in the synovial inflammation of RA[ J]. Rheumatology (Oxford), 2008, 47(4): 442 -450.
  • 4Rannou F, Francois M, Corvol MT, et al. Cartilage breakdown in rheumatoid arthritis[J]. Joint Bone Spine, 2006, 73(1 ): 29-36.
  • 5Kamata K, Kamijo S, Nakajima A, et al. Involvement of TNF-like weak inducer of apoptosis in the pathogenesis of collagen-induced arthritis[J]. J Immunol, 2006, 177(9):6433-6439.
  • 6Perper SJ, Browning B, Burkly LC, et al. TWEAK is a novel arthritogenic mediator [ J ]. J Immunol, 2006, 177 (4) : 2610 - 2620.
  • 7Nanki T. Molecular mechanisms of bone destruction in rheumatoid arthritis[J]. Clin Calcium, 2007, 17(4) : 510 -516.
  • 8Han S, Yoon K, Lee K, et al. TNF-related weak inducer of apoptosis receptor, a TNF receptor superfamily member, activates NF-kappa B through TNF receptor-associated factors [ J ]. Biochem Biophys Res Commun, 2003, 305(4): 789-796.
  • 9Yepes M, Winkles JA. Inhibition of TWEAK activity as a new treatment for inflammatory and degenerative diseases[ J]. Drug News Perspect, 2006 , 19(10) : 589 -595.

共引文献9

同被引文献33

  • 1杨再兴,梁艳,朱烨,李畅,张玲珍,仲人前.强直性脊柱炎患者血清IL-12水平及临床意义研究[J].中国实验诊断学,2007,11(5):619-621. 被引量：10
  • 2Zhu Xiangyang,Yao Lutian,Zhao Lin,Xia Liping,Shen Hui,Lu Jing.Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis[J].Cytokine.2012(1)
  • 3Dominique Talabot-Ayer,Thomas McKee,Patrizia Gindre,Sylvette Bas,Dominique L. Baeten,Cem Gabay,Gaby Palmer.Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis[J].Joint Bone Spine.2011(1)
  • 4Jochen Schmitz,Alexander Owyang,Elizabeth Oldham,Yaoli Song,Erin Murphy,Terril K. McClanahan,Gerard Zurawski,Mehrdad Moshrefi,Jinzhong Qin,Xiaoxia Li,Daniel M. Gorman,J. Fernando Bazan,Robert A. Kastelein.IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines[J].Immunity.2005(5)
  • 5Smith JA. Update on ankylosing spondylitis: current concepts in pathogenesis [J]. Curr Allergy Asthma Rep, 2015, 15(1) :489.
  • 6Park MC, Chung SJ, Park YB, et al. Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti-TNF treatment in patients with rheumatoid arthritis [J]. Scand J Rheumatol, 2008, 37(3) : 173-178.
  • 7Chen WS, Chang YS, Lin KC, et al. Association of serum in- terleukin-17 and interleukin-23 levels with disease activity in Chinese patients with ankylosing spondylitis [J]. J Chin Med Assoc, 2012, 75(7):303-308.
  • 8Van der Linden S, Valkenhurg HA, Cats A. Evaluation of diag- nostic criteria for ankylosing spondylitis. A proposal for modifi- cation of the New York criteria [J]. Arthritis Rheum, 1984, 27 (4) :361-368.
  • 9Calin A, Garrett S, Whitelock H, etal. A new approach to de- fining functional ability in ankylosing spondylitis: the develop- ment of the Bath Ankylosing Spondylitis Functional Index [J]. J Rheumatol, 1994, 21(12) :2281-2285.
  • 10Jakubowski A, Browning B, Lukashev M, et al. Dual role for TWEAK in angiogenic regulation [J]. J Cell Sci, 2002, 115(2) : 267-274.

引证文献3

二级引证文献5

中华临床医师杂志（电子版）
2012年 第3期

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