左心房功能指数在评价高血压患者左心房功能中的应用

Value of the left atrial function index for assessing left atrial function in patients with essential hypertension

目的应用超声心动图技术检测左心房功能指数,以评价高血压患者的左心房功能变化。方法选择60例高血压患者和31例健康对照者,记录身高、体重,常规测量左心房内径(LAD)、左心室流出道血流的速度时间积分(LVOT-VTI),采用双平面法测量左心房最大容积(LAESV)、左心房射血分数(LAEF),计算左心房搏出量(LASV)及左心房功能指数(LAFI),利用组织多普勒测量二尖瓣环运动频谱(Ea、Aa),并且计算Ea/Aa比值。结果高血压患者的LAFI较健康对照者降低(0.53±0.19 vs.0.79±0.23,P<0.05),高血压组内LAD增大者的LAFI较LAD正常范围者降低(0.47±0.18 vs.0.58±0.18,P<0.05);LAFI与Ea、Aa、Ea/Aa、LAD、LASV、LAEF进行相关性分析,结果示LAFI与Ea(r=0.43,P<0.001)、Ea/Aa(r=0.29,P<0.005)、LAEF(r=0.59,P<0.001)呈正相关,与LAD(r=-0.53,P<0.001)、LASV(r=-0.49,P<0.001)呈负相关。结论高血压患者LAFI减低,LAFI是评价左心房功能变化有意义的指标。

Objective To evaluate the left atrial function with the left atrial function index（LAFI） in patients with essential hypertension using echocardiography.Methods Sixty hypertensive patients and 31 normal controls were selected.The height,weight,diameter of left atrium（LAD）,mitral annular motion velocity（Ea,Aa）and the outflow tract velocity time integral（LVOT-VTI）were measured,and the Ea/Aa was calculated.Maximal LA volume（LAESV）,left atrial ejection fraction（LAEF）were measured using the biplane method of discs,left atrial stroke volume（LASV）and LAFI were calculated.Results The LAFI in the hypertensive patients group was depressed when compared with normal controls（0.53±0.19 vs.0.79±0.23,P0.05）.Among hypertensive patients,the LAFI of those having the larger LAD was lower than those having the normal LAD（0.47±0.18 vs.0.58±0.18,P0.05）.A linear regression analysis showed LAFI correlated well with Ea（r=0.43,P0.001）,Ea/Aa（r=0.29,P0.005）,LAEF（r=0.59,P0.001）;LAFI negatively correlated with LAD（r=-0.53,P0.001）and LASV（r=-0.49,P0.001）.Conclusions LAFI depresses in hypertensive patients,LAFI is a significant indicator in detecting the left atrial function.