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miR一146a在自身免疫性疾病发病机制及临床诊疗研究中的进展 被引量：5

The potential role of miR-146a in the pathogenesis and diagnosis of autoimmune diseases
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摘要 微小mRNA（miR）是一类长约22个核苷酸的非编码RNA，通过作用于相应mRNA在转录后水平调节基因表达，在炎性反应和自身免疫病中发挥重要作用。近期关于miR一146a在自身免疫性疾病中发挥作用的研究备受关注。在此对miR-146a与几种常见自身免疫性疾病发病机制的相关性及其潜在临床应用价值进行阐述。（手华检验医学杂志，2012，35：202-206） MicroRNA（miR）, a type of 22nt non-coding RNA, modulate gene expression at post- transcriptional level by interacting with targeting mRNA and play an important role in both inflammatory reaction and autoimmune diseases. Especially, the expression of miR-146a in autoimmune diseases has gotten more and more attention in recent studies. This review summarized the correlation between the expression of miR-146a and the pathogenesis of some common autoimmune diseases. What＇s more, the potential role of miR-146a in the clinical diagnosis of autoimmune diseases are also discussed. （Chin J Lab Med, 2012,35： 202-206）
作者 贾婷婷 王露楠
机构地区 北京协和医学院研究生院卫生部北京医院卫生部临床检验中心免疫室
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2012年第3期202-206,共5页 Chinese Journal of Laboratory Medicine
关键词 自身免疫疾病 微小RNAS 关节炎 类风湿 红斑狼疮 系统性 Autoimmune diseases MicroRNAs Arthritis,rheumatoid Lupus erythematosus,systemic
分类号 R593.2 [医药卫生—内科学]
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参考文献51

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同被引文献56

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中华检验医学杂志
2012年 第3期

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