纳络酮治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭疗效观察

Effects of naloxone on treatment of type Ⅱ respiratory failure of chronic obstructive pulmonary disease

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)合并Ⅱ型呼吸衰竭应用纳络酮治疗的效果。方法:将69例COPD合并Ⅱ型呼吸衰竭患者随机分为2组,对照组34例,并发肺性脑病16例,给予常规治疗;治疗组35例,并发肺性脑病18例,在常规治疗的基础上加用纳络酮1.0 mg加生理盐水20 ml静脉注射,每天2次。2组均6 d为一疗程。观察2组呼吸衰竭和肺性脑病恢复时间及动脉血气分析的变化。结果:治疗组在呼吸衰竭恢复时间和肺性脑病苏醒时间,以及血气分析水平改善方面均优于对照组(P<0.05～P<0.01)。结论:纳络酮治疗COPD合并Ⅱ型呼吸衰竭有较高的临床应用价值。

Objective：To explore the therapeutic effect of naloxone on the treatment of chronic obstructive pulmonary disease（COPD） complicated with type Ⅱ respiratory failure.Methods：Sixty-nine consecutive patients with COPD complicated with type Ⅱ respiratory failure were randomly divided into two groups：control group and therapy group.Thirty-four patients were in control group,16 of them had pulmonary encephalopathy.They were received conventional therapy.While 35 patients were in therapy group,18 of them had pulmonary encephalopathy.In therapy group,1.0 mg of naloxone and 20 ml normal saline were intravenously infused twice one day in addition to conventional treatment,6 days for a course of treatment.The recovery time of pulmonary encephalopathy and the changes of blood gas analysis in the two groups were observed.Results：There was significant improvement in therapy group about the recovery time of respiratory failure and pulmonary encephalopathy and the improvement of blood gas analysis compared to control group（P〈0.05-P〈0.01）.Conclusions：Naloxone has the significant therapeutic effect in treatment of COPD complicated with type Ⅱ respiratory failure.