青兰浸膏片治疗慢性阻塞性肺疾病患者临床疗效观察及机制研究

Clinical research on qinglan jingao tabales for the treatment of patients with chronic obstructive pulmonary disease

目的探索青兰浸膏片对慢性阻塞性肺疾病（COPD）的防治作用及可能的抗炎机制。方法本研究以青兰浸膏片治疗慢性阻塞性肺疾病急性加重期（AECOPD）患者为研究对象，采用酶联免疫吸附法测定患者治疗前后血清肿瘤坏死因子a（TNF-a）、白介素8（IL-8）水平，同时进行肺功能测定，比较观察青兰浸膏片治疗前后患者血清TNF—a、IL-8及肺功能的变化，并对其变化进行相关性研究。结果青兰浸膏片治疗AECOPD患者后血清TNF-a、IL-8水平明显下降（P〈0．01），英国医学研究会（MRC）呼吸困难评分明显降低（P〈0．01），肺功能FEV1％pred、FEV1／FVC、MVV、PEF有明显改善（P〈0．01）。结论青兰浸膏片治疗能明显下降AECOPD患者血清TNF-a和IL-8水平，明显改善呼吸困难程度及肺的通气功能。

Objective To explore possible preventive effect and anti-inflammatory mechanism of qinglan jingao tahales in the treatment of chronic obstructive pulmonary disease （COPD）. Methods In this study, patients with acute exacerbation stage of chronic obstructive pulmonary disease （AECOPD） by qinglan jingao tabales treatment were treated as the object of study. The serum levels of TNF-a and IL-8 before and after treatment were measured by ELISA method. Meanwhile lung function measurement. To observe the changes of serum TNF-a, IL-8 and pulmonary function in patients with COPD before and after qinglan jingao tabales treatment by comparison, and tO study the relationship between them. Results Patients with AECOPD have been treated by qinglan jingao tabales, the concentration TNF-a, IL-8 levels decreased significantly（ P〈0.01）, MRC dyspnea score was significantly lower（ P〈0.01）, lung function FEV1%pred,FEV1/FVC,MVV,PEF improved significantly （ P〈0.01）. Conclusions Qinglan jingao tabales treatment significantly decreased AECOPD serum TNF-a and IL-8 levels, significantly improved dyspnea and pulmonary ventilation function.