肥胖人群并发支气管哮喘的可能机制——氧化应激

Obesity-bronchial asthma potential mechanism -- oxidative stress

流行病学显示肥胖会增加支气管哮喘患病率和发病率，尽管对二者间联系研究已超过十余年，这种关联确切机制仍不清楚。肥胖人群氧化应激增加，氧化标记物在支气管哮喘患者亦有升高。氧化应激可能是肥胖人群并发支气管哮喘的机制。瘦素与脂连素比值增加，氧化应激增强。脂肪组织含量高，炎症介质增加，氧化应激增强。支气管哮喘患者氧化应激增强，氧化与抗氧化失衡。肥胖与支气管哮喘基因重合序列中存在炎症介质相关基因，同时患有肥胖与支气管哮喘的个体无论在肺脏局部还是全身循环中都可找到炎症反应及氧化应激证据，氧化应激极可能为肥胖与支气管哮喘反应链上关键环节。

Epidemiologic data suggests that obesity increases bronchial asthma （asthma） prevalence and incidence. Although the associations between obesity and asthma have been studied for more than one decade, indeed mechanism is still unknown, Oxidative stress levels are elevated in human obesity. Biomarkers of oxidative stress are increased in asthma. Oxidative stress may be obesity-asthma mechanism. Leptin-adiponectin ratio increasing induces oxidative stress. Adipose tissue content makes inflammation mediators to produce more, which induces oxidative stress. Levels of oxidative stress are increased in asthma, and there is oxidant/antioxidant imbalance. There are genes inflammation-associated in overlap regions linked to two conditions. Evidence of inflammations and oxidative stress could be found not only in lung but also in the circulation of obesity-asthma people. Oxidative stress is extremely liked to be the key point to obesity-asthma mechanism.