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RRM1在晚期非小细胞肺癌中的表达及其对吉西他滨+顺铂化疗效果的影响 被引量：1

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摘要 目的研究核糖核苷酸还原酶M1(RRM1)在晚期非小细胞肺癌(NSCLC)中的表达及与吉西他滨+顺铂化疗敏感性的关系。方法运用免疫组织化学PV-9000二步法,检测30例初治ⅢB以上非小细胞肺癌患者中RRM1的表达与临床病理参数及与吉西他滨(简称GEM)+顺铂方案化疗敏感性,以及吉西他滨+顺铂化疗与临床病理参数的关系。结果非小细胞肺癌组织中RRM1的阳性率为56.67%,非小细胞肺癌组织中RRM1表达及吉西他滨+顺铂化疗疗效与患者的性别、年龄、吸烟、病理分型均未见相关性(P<0.05)。RRM1阳性者接受吉西他滨+顺铂的有效率低于RRM1阴性表达者,两者间的差异有统计学意义(P=0.035)。结论 RRM1的表达可作为非小细胞肺癌患者吉西他滨+顺铂方案化疗敏感性的指标之一,RRM1低表达患者从吉西他滨+顺铂方案化疗方案中获益。
作者 张献波 董英辉 胡跃云
机构地区 河北省石家庄市第一医院肿瘤内科
出处 《河北医药》 CAS 2012年第8期1141-1143,共3页 Hebei Medical Journal
基金 河北省科学技术研究与发展支撑计划项目(编号:09276121)
关键词 肺肿瘤 核糖核苷酸还原酶 吉西他滨 免疫组织化学 敏感性 化疗
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

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河北医药
2012年 第8期

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