呫吨类化合物光物理特性与脂水分配系数的测定及其抗氧化性研究

Study on photophysical properties,liposome-water partition coefficients,and antioxidant activity of xanthenes

目的研究本课题组已报道的2个呫吨化合物(3a和3b)的光物理特性、脂水分配系数及抗氧化作用。方法将化合物溶解于不同溶剂中,紫外-可见分光光度计扫描紫外吸收光谱和荧光仪检测化合物荧光光谱;摇瓶法测定化合物的脂水分配系数,并测定化合物的清除羟基自由基的抗氧化性质。结果溶剂对化合物的光物理特性有影响,化合物3a和3b的正辛醇/水分配系数分别为0.23和0.38,抗氧化率分别是0.6%～36.4%和6.7%～54.4%。结论呫吨化合物具有适当的脂水分配系数和较强的抗氧化性,是潜在的抗氧化药物。

Objective To study on photophysical properties,liposome-water partition coefficients and antioxidant activity of two xanthenes（3a and 3b）.Methods These compounds were solved in different solvents and analyzed by UV spectroscopy and fuorescence spectroscopy.The lipophilicity was determined by the ＂shake flask＂ method,and the antioxidant activity was assessed with scavenging hydroxyl radical（·OH）.Results Different solvents may influence the photophysical properties of the compounds.The partition coefficients in n-octnol/water are 0.23 for 3a and 0.38 for 3b,and the suppression ratio against ·OH ranged from 0.6%~36.4% for compound 3a,6.7%~54.4% for compound 3b,respectively.Conclusion The two compounds have moderate liposome-water partition coefficients and high antioxidant activity,which may be potent antioxidant candidates.