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NEDD9在胃癌组织中的表达及意义 被引量：4

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摘要 目的研究NEDD9在胃癌组织中的表达及意义。方法采用免疫组织化学法检测NEDD9在胃癌组织、癌旁组织中的表达,并用单因素方差分析法研究其与临床病理因素的关系。结果 NEDD9表达阳性率在胃癌组织中比在癌旁组织中高,差异有统计学意义(P<0.05);NEDD9在胃癌中的表达与患者的性别、年龄、肿瘤大小无关(P>0.05),与TNM分期及肿瘤组织分化程度有关(P<0.05)。结论 NEDD9的高表达可以反映人类胃癌的恶性生物学行为及在人类胃癌的发生过程中起着重要作用,对胃癌诊断及判断预后有一定的意义,有可能成为判断胃癌预后的一个生物标记。
作者 汪涛 徐美荣 王鼎 徐俊飞 汝凯
机构地区 南通大学附属医院普外科四病区 南通市肿瘤医院普外科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第7期134-136,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 胃肿瘤 免疫组织化学 NEDD9
分类号 R735.2 [医药卫生—肿瘤]
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参考文献14

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  • 2刘福囝,滕勇,张晓旭,黎瀚,刘璐,孙瑞佳,徐惠绵.miR-210在胃癌组织中的表达及临床意义[J].中华临床医师杂志（电子版）,2011,5(9):2701-2703. 被引量：5
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二级参考文献11

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共引文献4

同被引文献37

  • 1Feng Y, Wang Y, Wang Z, et al. The CRTCI-NEDD9 signaling axis mediates lung cancer progession caused by LKBI loss[ J ]. Cancer Res, 2012, 72(24): 6502-6511.
  • 2O'Neill GM, Seo S, Serebriiskii IG. et al. A new central scaffold for metastasis: parsing HEF1/Cas-L/NEDD9. Cancer Res, 2007, 67 (19) : 8975-8979.
  • 3Li Y, Bavarva JH, Wang Z, et al. HEFI, a novel target of Wntsignaling, promotes colonic cell migration and cancer progression. Oncogene, 2011, 30 (23) : 2633-2643.
  • 4Astier A, Mani 6 SN, Avraham H, et al. The related adhesion focal tyrosine kinase differentially phosphorylates pl30Cas and the Cas-like protein, pl05HEF1. J Biol Chem, 1997, 272 (32) : 19719-19724.
  • 5Guo W, Ren D, Chen X, et al. HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under theregulation of microRNA-145. J Cell Biochem, 2013, 114 (7) : 1606-1615.
  • 6Kim M, Gans JD, Nogueira C, et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell, 2006, 125 (7) : 1269-1281.
  • 7Li Y, Bavarva JH, Wang Z, et al. HEF1, a novel target of Wnt signaling, promotes colonic cell migration and cancer progression. Oncogene, 2011, 30 (23) : 2633-2643.
  • 8Speranza MC, Frattini V, Pisati F, et al. NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma. Oncotarget, 2012, 3 (7) : 723-734.
  • 9Natarajan M, Stewart JE, Golemis EA, et al . HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells. Oncogene, 2006, 25 (12) : 1721-1732.
  • 10Kumar S,Tomooka Y,Noda M.Identification of a set of genes with developmentally down-regulated expression in the mouse brain[J].Biochem Biophys Res Commun,1992,185(3):1155-1161.

引证文献4

二级引证文献2

中华临床医师杂志（电子版）
2012年 第7期

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