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葡萄糖转运蛋白4与糖尿病胰岛素抵抗相关性研究进展 被引量：4

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摘要 糖尿病是葡萄糖的利用障碍与生成增加，导致血液中葡萄糖浓度增加，碳：水化合物、脂肪、蛋白质等代谢紊乱，多种器官慢性损伤、功能障碍和衰竭的一种疾病。Yang等研究显示：糖尿病目前已成为中国主要的公共卫生问题，糖尿病总发病率和前糖尿病状态分别为9．7％和15．5％，即我国约有9240万成年糖尿病患者和1亿4820万人处于前糖尿病状态。
作者 刘菊华 严宗逊
机构地区 川北医学院附属医院内分泌科
出处 《中华临床医师杂志（电子版）》 CAS 2012年第8期133-135,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 糖尿病胰岛素抵抗 葡萄糖转运蛋白4 相关性 公共卫生问题 葡萄糖浓度 水化合物 代谢紊乱 慢性损伤
分类号 R587.1 [医药卫生—内分泌]
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参考文献32

  • 1Yang WY,Lu JM,Weng JP. Prevalence of diabetes among men and women in China[J].New England Journal of Medicine,2010.1090-1101.doi:10.1056/NEJMoa0908292.
  • 2Abel ED,Peroni O,Kim JK. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver[J].Nature,2001.729-733.
  • 3Taegtmeyer H,McNulty P,Young ME. Adaptation and maladaptation of the heart in diabetes.Part Ⅰ:general concepts[J].Circulation,2002.1727-1733.
  • 4Kanzaki M. Insulin receptor signals regulating GLUT4 translocation and actin dynamics[J].Endocrine Journal,2006.267-293.
  • 5Watson RT,Pessin JE. Intracellular organization of insulin signaling and GLUT4 translocation[J].Recent Progress in Hormone Research,2001.175-193.
  • 6Marshall BA,Hansen PA,Ensor NJ. GLUT-1 or GLUT-4 transgenes in obese mice improve glucose tolerance but do not prevent insulin resistance[J].American Journal of Physiology,1999.390-400.
  • 7Waller AP,Burns TA,Mudge MC. Insulin resistance selectively alters cell-surface glucose transporters but not their total Protein expression in equine skeletal muscle[J].Journal of Veterinary Internal Medicine,2011.315-321.
  • 8Kelly KR,Kashyap SR,O′Leary VB. Retinol-binding protein 4(RBP4)protein expression is increa sed in omental adipose tissue of severely obese patients[J].Obesity,2010.663-666.
  • 9Kouidhi S,Berrhouma R,Rouissi K. Human subcutaneous adipose tissue Glut 4 mRNA expression in obesity and type 2 diabetes[J].ACTA DIABETOLOGICA,2011.
  • 10Bajaj M,Pratipanawatr T,Berria R. Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes[J].Diabetes,2002.3043-3048.

二级参考文献14

  • 1Mahgoub MA, Abd-Elfattah AS. Diabetes mellitus and cardiac function. Mol Cell Biochem, 1998, 180:59-64.
  • 2Korvald C,Elvenes OP,Myrmel T. Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol, 2000,278: H1345-1351.
  • 3Reed MJ, Meszaros K, Entes LJ, et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism, 2000,49:1390-1394.
  • 4Lopaschuk GD, Barr RL. Measurements of fatty acid and carbohydrate metabolism in theisolated working rat heart. Mol Cell Biochem, 1997,172:137-147.
  • 5Chandler MP, Huang H, McElfresh TA, et al. Increased nonoxidative glycolysis despite continued fatty acid uptake during demand-induced myocardial ischemia. Am J Physiol Heart Circ Physiol,2002,282:H1871-1878.
  • 6Lopaschuk GD. Optimizing cardiac energy metabolism: how can fatty acid andcarbohydrate metabolism be manipulated? Coron Artery Dis, 2001,12 Suppl 1:S8-11.
  • 7Longnus SL, Wambolt RB, Barr RL, et al. Regulation of myocardial fatty acid oxidation by substrate supply. Am J Physiol Heart Circ Physiol, 2001, 281:H1561-1567.
  • 8Abel ED. Glucose transport in the heart. Front Biosci, 2004, 9:201-215.
  • 9Depre CD, Vanoverschelde JL,Taegtmeyer H. Glucose for the heart. Circulation, 1999,99: 578-588.
  • 10Rodrigues B, Cam MC, McNeil JH. Metabolic disturbances in diabetic cardiomyopathy. Mol Cell Biochem, 1998,180:53-57.

共引文献11

同被引文献28

引证文献4

二级引证文献6

中华临床医师杂志（电子版）
2012年 第8期

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