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CD133及Notch1基因在上皮性卵巢癌组织中的表达及意义 被引量:4

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摘要 目的探讨卵巢癌中CD133及Notch1的表达情况及其临床病理学意义。方法采用免疫组化方法检测46例上皮性卵巢癌、18例腺瘤及10例正常卵巢组织中CD133及Notch1的表达情况。结果正常卵巢组织、腺瘤及卵巢癌中CD133及Notch1的表达呈升高趋势,组间差异有统计学意义(P<0.05)。CD133表达水平与卵巢癌的分期、病理分级及淋巴结转移相关(P<0.05),而与年龄及组织学类型无关,Notch1表达水平与卵巢癌的病理分级及淋巴结转移相关(P<0.05),而与分期、年龄及组织学类型无关。Spearman相关性分析显示CD133表达与Notch1的表达呈正相关(r=0.401,P<0.05)。结论 CD133及Notch1的高表达可能与卵巢癌的发生、发展有关。
出处 《中华临床医师杂志(电子版)》 CAS 2012年第8期157-159,共3页 Chinese Journal of Clinicians(Electronic Edition)
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参考文献10

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同被引文献48

  • 1黄啸,蔡树模,汤洁,李子庭,臧荣余.综合性治疗复发性卵巢上皮性癌的疗效及预后分析[J].中华妇产科杂志,2004,39(9):602-605. 被引量:18
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