甲型H1N1流感患者外周血淋巴细胞变化

Dynamic of peripheral blood lymphocytes in patients with influenza A(H1N1)

目的:寻求甲型H1N1流感患者外周血淋巴细胞与病情的相关性。方法:比较经实时RT-PCR确诊的183例普通型和64例重症型甲型H1N1流感患者外周血淋巴细胞,分析淋巴细胞计数与疾病分型及病情的相关性。结果:治疗前甲型H1N1流感重症型患者淋巴细胞计数[(1.23±0.76)×109L-1]较普通型患者[(1.50±0.59)×109L-1]明显偏低(t=2.958,P<0.01);治疗后患者淋巴细胞计数[(1.92±0.79)×109L-1]较治疗前[(1.27±0.63)×109L-1]明显上升(t=6.33,P<0.01)。结论:淋巴细胞计数对甲型H1N1流感患者临床分型及病情变化有预测作用。

Objective：To explore the relationship between peripheral lymphocyte counts and severity of the disease among H1N1 influenza patients.Methods：Patients infected with the H1N1 virus,including 183 simple and 64 severe cases,were confirmed by real-time reverse-transcriptase-polymerase-chain-reaction assay.Datas of the peripheral lymphocyte counts and clinical features were collected and evaluated.Results：Peripheral lymphocyte counts in severe patients were significantly lower compared with that in simple group[（1.23 ± 0.76） × 10 9 L-1 vs（1.50 ± 0.59） × 10 9 L-1,t =2.958,P 0.01） ].Total lymphocytes counts significantly increased after treatment[（1.92 ± 0.79） × 10 9 L-1） vs（1.27 ±0.63） ×10 9 L-1,t =6.33,P 0.01） ].Conclusion：Peripheral lymphocyte counts may be associated with the prognosis of the H1N1 influenza.