直肠神经内分泌肿瘤的分布特征与治疗

Neuroendocrine tumor of the rectum:distribution features and treatment

目的:总结直肠神经内分泌肿瘤(NET)的分布特征与外科治疗策略。方法:回顾性分析我院2006年1月至2011年4月7例经治疗的直肠NET患者的临床资料,并对患者进行随访。结果:7例直肠NET占同期直肠恶性肿瘤的1.1%,男性5例,女性2例,其中5例在距肛缘10 cm以内,占71%。3例经肛门行局部扩大切除;3例行内镜下黏膜切除,其中2例术后病理基底部无肿瘤,进行常规随访,1例术后病理检查基底见癌细胞,进行经肛局部扩大切除;另外1例患者肿瘤距肛缘10 cm,直径1.5 cm,行直肠经腹前切除术。7例患者均得到随访,现正常存活。结论:直肠NET临床少见,发生于直肠远端较多,男性多于女性,其外科手术原则与直肠腺癌相似。

Objective：To study the distribution features and treatment of neuroendocrine tumor（NET）.Methods：Retrospective analysis,follow-up study and literature review of 7 treated NET patients were done in Nanjing Luhe People＇s Hospital from January,2006 to April,2011.Results：Seven rectum NET cases accounted for 1.1% in all rectum tumor cases at the same time period in NHTCM,including 5 males and 2 females.Five patients（71%） with tumor located within 10 cm from the anal verge.Three patients received local wide excision,3 patients received endoscopic mucosal resection,after surgery,histopathologic examination showed that two patients had no carcinoma cells in the tumor base,1 had carcinoma cells in the tumor base and then received local wide excision.The tumor of the 7th patient was 1.5 cm in diameter and located at 10 cm from the anal verge and the patient received rectum anterior resection.All patients were followed up and they all survive now.Conclusion：Rectum NET cases are uncommon.It often occurs at the far end of rectum and it happens more in male than in female.The surgery principles for rectum NET are similar with those in rectal adenocarcinoma.