摘要
目的探讨PON1基因Q192R位点在广西巴马地区不同人群中的频率及PON1基因多态性与巴马地区长寿现象的相关性。方法采用TaqMan探针实时荧光PCR技术对广西巴马长寿地区123例长寿老人(年龄90岁以上,长寿组)以及巴马长寿地区138例无长寿史的健康成年人(年龄24～87岁,对照1组)、巴马非长寿地区147例无长寿史的健康成年人(年龄48～89岁,对照2组)和南丹地区144例无长寿史的健康成年人(年龄21～83岁,对照3组)的PON1基因进行基因分型。结果长寿组与各对照组比较,等位基因和基因型分布差异存在统计学意义(P<0.05)。结论该多态性位点与地域有关,与巴马长寿地区的长寿现象是否有关还需进一步验证。
Objective To investigate the correlation between Q192R single nucleotide polymorphisms（SNP） of PON1 gene and hu- man longevity in Bama county. Methods Genotyping of PON1 gene was performed by TaqMan-PCR technique for 123 longevous people （aged 90 - 110, longevity group） from Bama longevity area, 138 healthy cases without long life history from the same area （aged 24 - 87, control group 1 ）, 147 healthy cases without long life history from Bama non-longevity area （aged 48 - 89 ,control group 2） and 143 healthy controls without long life history from Nandan （aged 21-83, control group 3）. Results There were statistically significant change of some frequencies of alleles and genotypes between longevity group and control group 3 （ P 〈 O. 05）. Conclusions These data suggest a modest as- sociation between the PON1 gene Q192R and district. It needs a further research to confirm whether there have any relationship between PON1 gene Q192R and longevity phenomenon in Bama longevity area.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2012年第7期1338-1340,共3页
Chinese Journal of Gerontology
基金
国家自然科学基金资助项目(No.30560166
No.81060246)
广西科学基金资助项目(桂科自0991115桂科青0832032)
广西科学研究与技术开发项目(桂科能0815011-6-5)
