94例新生儿呼吸机相关性肺炎临床分析

A Clinical Analysis of 94 Cases of Neonatal Ventilator Associated Pneumonia

目的探讨新生儿呼吸机相关性肺炎(VAP)的危险因素。方法回顾性分析新生儿重症监护病房行机械通气患儿临床资料,其中发生VAP患儿94例,非VAP患儿109例,比较两组患儿性别、出生体重、胎龄、基础疾病、气管插管次数、侵入性操作、机械通气时间、病情变化情况、住院时间等数据。结果体重越小,VAP发病率越高,VAP和非VAP患儿平均胎龄分别为34.12±3.24周和36.23±3.12周,两组比较差异明显(P<0.05);两组患儿气管插管次数和住院时间比较差异明显(P=0.006和P=0.005)。结论 VAP的发生与新生儿胎龄、出生体重等内因密切相关,同时气管插管次数、住院时间等外部因素也能在很大程度上影响VAP的发病。

Objective To investigate the risk factors of neonatal ventilator-associated pneumonia（VAP）.Methods A retrospective analysis was made on the clinical data of 203 cases of neonatal in intensive care unit by mechanical ventilation,involving two groups： 94cases of VAP and 109 cases of Non-VAP.Two groups were compared in terms of gender,birth weight,gestational age,underlying diseases,the times of tracheal intubation,invasive procedures,duration of mechanical ventilation,changes in condition and duration of hospitalization.Results The less weight,the higher morbidity of VAP is.The average gestational age with VAP was 34.12±3.24 weeks and the average gestational age with Non-VAP was 36.23±3.12 weeks.The result in two groups were significant different（P0.05）.The times of intubation and length of hospitalization in two groups were significantly different（P=0.006 and P=0.005）.Conclusion The morbidity of VAP was closely related to internal factors,such as the neonatal gestational age and birth weight.On the other hand,the external factors,such as tracheal intubation and hospitalization,could significantly affect the morbidity of VAP.