凋亡相关斑点样蛋白的研究进展

Research advances in the apoptosis-associated speck-like protein containing a CARD

凋亡相关斑点样蛋白(apoptosis-associated speck-like protein containing a CARD,ASC)是一种含有N端热蛋白样结构域和C端胱天氨酸募集结构域的接头分子。ASC可以通过它含有的同源蛋白互作结构域PYD和CARD的寡聚化来募集上下游与其含有同源结构域的其他蛋白,从而参与多条信号转导途径,在炎症反应、肿瘤发生、细胞凋亡和NF-κB信号通路的调节方面发挥重要的生物学作用。

Apoptosis-associated speck-like protein containing a CARD（ASC） is an adaptor protein that has a bipartite domain structure,an N-terminal pyrin domain（PYD） and a C-terminal caspase recruitment domain（CARD）.Recent researches demonstrate that ASC plays an important role in many signal pathways by it′s protein– protein interaction domains PYD and CARD,such as inflammations,tumor occurrences,apoptosis and the regulation of NF-κB.